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ABCA10 ATP binding cassette subfamily A member 10 [ Homo sapiens (human) ]

Gene ID: 10349, updated on 23-Nov-2021

Summary

Official Symbol
ABCA10provided by HGNC
Official Full Name
ATP binding cassette subfamily A member 10provided by HGNC
Primary source
HGNC:HGNC:30
See related
Ensembl:ENSG00000154263 MIM:612508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EST698739
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 9.1), fat (RPKM 3.8) and 18 other tissues See more
Orthologs
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Genomic context

See ABCA10 in Genome Data Viewer
Location:
17q24.3
Exon count:
40
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (69148007..69244848, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (67144148..67240989, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 6 Neighboring gene Sharpr-MPRA regulatory region 12590 Neighboring gene microRNA 4524b Neighboring gene microRNA 4524a Neighboring gene uncharacterized LOC100133319 Neighboring gene ATP binding cassette subfamily A member 5 Neighboring gene uncharacterized LOC105371878 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 4 Neighboring gene uncharacterized LOC105371879

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family A member 10
Names
ATP-binding cassette A10
ATP-binding cassette, sub-family A (ABC1), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377321.1NP_001364250.1  ATP-binding cassette sub-family A member 10

    Status: REVIEWED

    Source sequence(s)
    AC005495
    Related
    ENSP00000428032.1, ENST00000523419.5
    Conserved Domains (1) summary
    TIGR01257
    Location:371520
    rim_protein; retinal-specific rim ABC transporter
  2. NM_080282.4NP_525021.3  ATP-binding cassette sub-family A member 10

    See identical proteins and their annotated locations for NP_525021.3

    Status: REVIEWED

    Source sequence(s)
    AC005495, AY247065, C16161
    Consensus CDS
    CCDS11684.1
    UniProtKB/Swiss-Prot
    Q8WWZ4
    Related
    ENSP00000269081.4, ENST00000269081.8
    Conserved Domains (1) summary
    TIGR01257
    Location:371520
    rim_protein; retinal-specific rim ABC transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    69148007..69244848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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