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PCGF3 polycomb group ring finger 3 [ Homo sapiens (human) ]

Gene ID: 10336, updated on 2-Nov-2024

Summary

Official Symbol
PCGF3provided by HGNC
Official Full Name
polycomb group ring finger 3provided by HGNC
Primary source
HGNC:HGNC:10066
See related
Ensembl:ENSG00000185619 MIM:617543; AllianceGenome:HGNC:10066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF3; DONG1; RNF3A
Summary
The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 24.1), endometrium (RPKM 13.1) and 25 other tissues See more
Orthologs
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Genomic context

See PCGF3 in Genome Data Viewer
Location:
4p16.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (705832..770089)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (705458..767880)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (699621..763877)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:668197-668954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:674515-675154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:680358-681306 Neighboring gene uncharacterized LOC124900643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:682255-683203 Neighboring gene solute carrier family 49 member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:683204-684151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:686336-686923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:686924-687510 Neighboring gene myosin light chain 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:688618-689118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:694583-695083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:697641-698368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:699409-700394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:700395-701379 Neighboring gene uncharacterized LOC124900172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:720375-720890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:720891-721405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:725234-725734 Neighboring gene uncharacterized LOC107986246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15107 Neighboring gene uncharacterized LOC124900644 Neighboring gene chloride intracellular channel protein 6-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:759135-759682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21134 Neighboring gene PCGF3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:762535-763476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:774752-775469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:775470-776186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:776187-776904 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:778899-779770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:781743-782244 Neighboring gene uncharacterized LOC105374339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:782245-782744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:783251-783750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:784983-785792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:793259-793758 Neighboring gene complexin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:823745-824262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:824263-824778 Neighboring gene uncharacterized LOC105374340

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ36550, FLJ43813, MGC40413, MGC129615, DKFZp686D20235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H2AK119 ubiquitin ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in random inactivation of X chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with X chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycomb group RING finger protein 3
Names
RING finger protein 3A
ring finger protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317836.3NP_001304765.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-7 all encode the same isoform (a).
    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
  2. NM_001395245.1NP_001382174.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
  3. NM_001395246.1NP_001382175.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
  4. NM_001395247.1NP_001382176.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
  5. NM_001395248.1NP_001382177.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
  6. NM_001395249.1NP_001382178.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
  7. NM_001395250.1NP_001382179.1  polycomb group RING finger protein 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    UniProtKB/TrEMBL
    B3KQ06, B3KWT8
    Conserved Domains (2) summary
    cd17083
    Location:120202
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cl17238
    Location:226
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  8. NM_001395251.1NP_001382180.1  polycomb group RING finger protein 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    UniProtKB/TrEMBL
    B3KQ06, B3KWT8
    Conserved Domains (2) summary
    cd17083
    Location:120202
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cl17238
    Location:226
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  9. NM_006315.7NP_006306.2  polycomb group RING finger protein 3 isoform a

    See identical proteins and their annotated locations for NP_006306.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1-7 all encode the same isoform (a).
    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Related
    ENSP00000354724.5, ENST00000362003.10
    Conserved Domains (2) summary
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    705832..770089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449500.1XP_047305456.1  polycomb group RING finger protein 3 isoform X1

    UniProtKB/TrEMBL
    B3KWT8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    705458..767880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348726.1XP_054204701.1  polycomb group RING finger protein 3 isoform X1

    UniProtKB/TrEMBL
    B3KWT8