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PCGF3 polycomb group ring finger 3 [ Homo sapiens (human) ]

Gene ID: 10336, updated on 5-Apr-2020

Summary

Official Symbol
PCGF3provided by HGNC
Official Full Name
polycomb group ring finger 3provided by HGNC
Primary source
HGNC:HGNC:10066
See related
Ensembl:ENSG00000185619 MIM:617543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF3; DONG1; RNF3A
Summary
The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 24.1), endometrium (RPKM 13.1) and 25 other tissues See more
Orthologs

Genomic context

See PCGF3 in Genome Data Viewer
Location:
4p16.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (705832..770980)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (699537..764428)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 49 member 3 Neighboring gene myosin light chain 5 Neighboring gene uncharacterized LOC107986245 Neighboring gene uncharacterized LOC107986246 Neighboring gene translation initiation factor IF-2 Neighboring gene uncharacterized LOC100129917 Neighboring gene uncharacterized LOC105374339 Neighboring gene complexin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36550, FLJ43813, MGC40413, MGC129615, DKFZp686D20235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone H2A-K119 monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H2A-K119 monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
inactivation of X chromosome by genetic imprinting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inactivation of X chromosome by genetic imprinting ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with X chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycomb group RING finger protein 3
Names
RING finger protein 3A
ring finger protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317836.2NP_001304765.1  polycomb group RING finger protein 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC139887, AK057124, AK093869, AK125801, AK300290, BC050044, BC107061, CX867889
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06, B3KWT8, B4DTN5
    Conserved Domains (2) summary
    pfam16207
    Location:172236
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
  2. NM_006315.6NP_006306.2  polycomb group RING finger protein 3

    See identical proteins and their annotated locations for NP_006306.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC107464, AC139887, BC050044, BI758022, BX640894, CX761238, CX761943
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    Q3KNV8
    Related
    ENSP00000354724.5, ENST00000362003.9
    Conserved Domains (2) summary
    pfam16207
    Location:172236
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16735
    Location:1460
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    705832..770980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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