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Traf3ip2 TRAF3 interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 103213, updated on 20-Feb-2024

Summary

Official Symbol
Traf3ip2provided by MGI
Official Full Name
TRAF3 interacting protein 2provided by MGI
Primary source
MGI:MGI:2143599
See related
Ensembl:ENSMUSG00000019842 AllianceGenome:MGI:2143599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Act1; CIKS
Summary
Enables signaling receptor binding activity and ubiquitin protein ligase activity. Involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and leukocyte homeostasis. Acts upstream of or within B cell apoptotic process and humoral immune response. Is active in cytoplasmic vesicle and nucleus. Used to study Sjogren's syndrome; atopic dermatitis; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Act1 (Gene ID:109776) and Traf3ip2 (Gene ID:103213) share the Act1 symbol/alias in common. Act1 is a widely used alternative name for adapter protein CIKS (Traf3ip2), which can be confused with the official symbol for Act1, actin related gene 1 (Act1). [15 Oct 2019]
Expression
Broad expression in colon adult (RPKM 15.9), ovary adult (RPKM 14.1) and 26 other tissues See more
Orthologs
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Genomic context

See Traf3ip2 in Genome Data Viewer
Location:
10 B1; 10 20.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39488930..39531303)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39612934..39655307)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:39089323-39089624 Neighboring gene Fyn proto-oncogene Neighboring gene STARR-seq mESC enhancer starr_26390 Neighboring gene STARR-seq mESC enhancer starr_26392 Neighboring gene predicted gene 16364 Neighboring gene STARR-seq mESC enhancer starr_26396 Neighboring gene predicted gene, 40627 Neighboring gene RIKEN cDNA E130307A14 gene Neighboring gene STARR-seq mESC enhancer starr_26400 Neighboring gene predicted gene 8899 Neighboring gene predicted gene, 53621

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell affinity maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell mediated immunity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in CD40 signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-helper 17 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interleukin-17 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine production involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eosinophil homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eosinophil mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immunoglobulin production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-17A-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-17A-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-17A-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte activation involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to P-body IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cytokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transitional two stage B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin ligase TRAF3IP2
Names
E3 ubiquitin-protein ligase CIKS
adapter protein CIKS
connection to IKK and SAPK/JNK
nuclear factor NF-kappa-B activator 1
NP_598761.2
XP_011241407.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134000.3NP_598761.2  E3 ubiquitin ligase TRAF3IP2

    See identical proteins and their annotated locations for NP_598761.2

    Status: VALIDATED

    Source sequence(s)
    AC160403
    Consensus CDS
    CCDS23789.1
    UniProtKB/Swiss-Prot
    Q8BH33, Q8N7N6
    UniProtKB/TrEMBL
    Q8C0E5
    Related
    ENSMUSP00000019987.7, ENSMUST00000019987.7
    Conserved Domains (2) summary
    PRK10263
    Location:217373
    PRK10263; DNA translocase FtsK; Provisional
    pfam08357
    Location:391533
    SEFIR; SEFIR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    39488930..39531303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243105.2XP_011241407.1  E3 ubiquitin ligase TRAF3IP2 isoform X1

    UniProtKB/TrEMBL
    Q8C0E5
    Conserved Domains (2) summary
    PRK10263
    Location:245401
    PRK10263; DNA translocase FtsK; Provisional
    pfam08357
    Location:419561
    SEFIR; SEFIR domain