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CRISP3 cysteine rich secretory protein 3 [ Homo sapiens (human) ]

Gene ID: 10321, updated on 8-Jul-2021

Summary

Official Symbol
CRISP3provided by HGNC
Official Full Name
cysteine rich secretory protein 3provided by HGNC
Primary source
HGNC:HGNC:16904
See related
Ensembl:ENSG00000096006 MIM:618062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3
Summary
This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Expression
Biased expression in salivary gland (RPKM 504.8), bone marrow (RPKM 138.4) and 1 other tissue See more
Orthologs
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Genomic context

See CRISP3 in Genome Data Viewer
Location:
6p12.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (49727376..49744388, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49695089..49712101, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 217 Neighboring gene cysteine rich secretory protein 2 Neighboring gene phosphoglycerate kinase 2 Neighboring gene uncharacterized LOC101927020 Neighboring gene uncharacterized LOC101927048

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126588

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in defense response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in specific granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule lumen TAS
Traceable Author Statement
more info
 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cysteine-rich secretory protein 3
Names
specific granule protein (28 kDa)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190986.3NP_001177915.1  cysteine-rich secretory protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001177915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is longer than isoform 1.
    Source sequence(s)
    AL121950, BC069580, DB206136, X95240
    Consensus CDS
    CCDS55019.1
    UniProtKB/Swiss-Prot
    P54108
    Related
    ENSP00000389026.2, ENST00000433368.6
    Conserved Domains (2) summary
    cd05383
    Location:60197
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
    pfam08562
    Location:214268
    Crisp; Crisp
  2. NM_001368123.1NP_001355052.1  cysteine-rich secretory protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AL121950, AL121974, DB204588
    Related
    ENSP00000360201.4, ENST00000371159.8
  3. NM_006061.4NP_006052.2  cysteine-rich secretory protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006052.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL121950, DB210604, X95240
    Consensus CDS
    CCDS4929.2
    UniProtKB/Swiss-Prot
    P54108
    Related
    ENSP00000263045.4, ENST00000263045.9
    Conserved Domains (2) summary
    cd05383
    Location:50187
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
    pfam08562
    Location:204258
    Crisp; Crisp

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    49727376..49744388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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