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NMUR1 neuromedin U receptor 1 [ Homo sapiens (human) ]

Gene ID: 10316, updated on 21-Dec-2019

Summary

Official Symbol
NMUR1provided by HGNC
Official Full Name
neuromedin U receptor 1provided by HGNC
Primary source
HGNC:HGNC:4518
See related
Ensembl:ENSG00000171596 MIM:604153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FM3; FM-3; GPC-R; GPR66; NMU1R; (FM-3)
Expression
Broad expression in fat (RPKM 2.5), lung (RPKM 1.6) and 20 other tissues See more
Orthologs

Genomic context

See NMUR1 in Genome Data Viewer
Location:
2q37.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (231519903..231530456, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232387871..232395182, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 22, pseudogene Neighboring gene long intergenic non-protein coding RNA 471 Neighboring gene uncharacterized LOC105376787 Neighboring gene ribosomal protein L21 pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
neuromedin U binding IDA
Inferred from Direct Assay
more info
PubMed 
neuromedin U receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuromedin-U receptor 1
Names
G-protein coupled receptor 66
G-protein coupled receptor FM-3
NMU-R1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006056.5NP_006047.3  neuromedin-U receptor 1

    See identical proteins and their annotated locations for NP_006047.3

    Status: VALIDATED

    Source sequence(s)
    AC017104, AF272362, BP198644
    Consensus CDS
    CCDS2486.1
    UniProtKB/Swiss-Prot
    Q9HB89
    Related
    ENSP00000305877.4, ENST00000305141.5
    Conserved Domains (1) summary
    pfam00001
    Location:77356
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    231519903..231530456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712196.3XP_006712259.1  neuromedin-U receptor 1 isoform X4

    Conserved Domains (1) summary
    pfam00001
    Location:77249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_006712195.3XP_006712258.1  neuromedin-U receptor 1 isoform X3

    Conserved Domains (1) summary
    pfam00001
    Location:77249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011510488.2XP_011508790.1  neuromedin-U receptor 1 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:77249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_011510487.3XP_011508789.1  neuromedin-U receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011508789.1

    UniProtKB/Swiss-Prot
    Q9HB89
    Conserved Domains (1) summary
    pfam00001
    Location:54333
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. XM_011510489.2XP_011508791.1  neuromedin-U receptor 1 isoform X5

    Conserved Domains (1) summary
    pfam00001
    Location:77249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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