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Pwp1 PWP1 homolog, endonuclein [ Mus musculus (house mouse) ]

Gene ID: 103136, updated on 8-Feb-2024

Summary

Official Symbol
Pwp1provided by MGI
Official Full Name
PWP1 homolog, endonucleinprovided by MGI
Primary source
MGI:MGI:1914735
See related
Ensembl:ENSMUSG00000001785 AllianceGenome:MGI:1914735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310058A11Rik; 2610205J09Rik
Summary
Enables H4K20me3 modified histone binding activity. Acts upstream of or within histone H4-K20 trimethylation; negative regulation of peptidyl-serine phosphorylation of STAT protein; and positive regulation of stem cell differentiation. Located in nucleus. Is expressed in several structures, including brain; neural retina; and trachea. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 17.4), CNS E18 (RPKM 12.8) and 28 other tissues See more
Orthologs
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Genomic context

See Pwp1 in Genome Data Viewer
Location:
10 C1; 10 41.73 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (85707695..85724967)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (85871831..85889103)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1559 Neighboring gene predicted gene 6721 Neighboring gene uncharacterized protein C12orf73 homolog Neighboring gene PR domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E723 Neighboring gene achaete-scute family bHLH transcription factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables H4K20me3 modified histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone chaperone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
periodic tryptophan protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133993.3NP_598754.2  periodic tryptophan protein 1 homolog

    See identical proteins and their annotated locations for NP_598754.2

    Status: VALIDATED

    Source sequence(s)
    AK082158, BB032128, BY771053
    Consensus CDS
    CCDS24092.1
    UniProtKB/Swiss-Prot
    Q99LL5, Q9D6T6
    Related
    ENSMUSP00000001836.3, ENSMUST00000001836.11
    Conserved Domains (3) summary
    COG2319
    Location:252493
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:258295
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:252413
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    85707695..85724967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)