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CCNO cyclin O [ Homo sapiens (human) ]

Gene ID: 10309, updated on 7-Jun-2020

Summary

Official Symbol
CCNOprovided by HGNC
Official Full Name
cyclin Oprovided by HGNC
Primary source
HGNC:HGNC:18576
See related
Ensembl:ENSG00000152669 MIM:607752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCNU; UDG2; CILD29
Summary
This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]
Annotation information
Note: Due to a common symbol (UNG2) for the specific nuclear isoform of the UNG gene (GeneID 7374) and as a previous symbol for the CCNO gene (GeneID 10309), incorrect attributions of uracil DNA glycosylase activity have been made for CCNO in the scientific literature. CCNO was correctly identified as a cyclin protein family member in PubMed ID: 8419333. HIV-1 interacts with the UNG gene and not with the CCNO gene. [13 Feb 2013]
Expression
Broad expression in testis (RPKM 3.3), stomach (RPKM 2.3) and 16 other tissues See more
Orthologs

Genomic context

See CCNO in Genome Data Viewer
Location:
5q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55231152..55233717, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54526980..54529508, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cell division cycle 20B Neighboring gene microRNA 449c Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene uncharacterized LOC105378973 Neighboring gene DExH-box helicase 29 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene protein serine kinase H1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22422

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multi-ciliated epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-O
Names
cyclin U
cyclin domain containing

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034201.1 RefSeqGene

    Range
    5110..7566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021147.5NP_066970.3  cyclin-O

    See identical proteins and their annotated locations for NP_066970.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK026075, BC004877
    Consensus CDS
    CCDS34157.1
    UniProtKB/Swiss-Prot
    P22674
    Related
    ENSP00000282572.4, ENST00000282572.5
    Conserved Domains (2) summary
    pfam00134
    Location:108229
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:231296
    Cyclin_C; Cyclin, C-terminal domain

RNA

  1. NR_125346.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC004877, BI832060
    Related
    ENST00000501463.2
  2. NR_125347.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK026075, BC004877, BI832060, HY011414
  3. NR_125348.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-terminal exon, which extends past a splice site that is used in variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC017345

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    55231152..55233717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024592.1: Suppressed sequence

    Description
    NM_001024592.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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