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DLEU1 deleted in lymphocytic leukemia 1 [ Homo sapiens (human) ]

Gene ID: 10301, updated on 13-Nov-2022

Summary

Official Symbol
DLEU1provided by HGNC
Official Full Name
deleted in lymphocytic leukemia 1provided by HGNC
Primary source
HGNC:HGNC:13747
See related
Ensembl:ENSG00000176124 MIM:605765; AllianceGenome:HGNC:13747
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCMS; DLB1; LEU1; LEU2; XTP6; BCMS1; DLEU2; LINC00021; NCRNA00021
Expression
Ubiquitous expression in testis (RPKM 1.6), colon (RPKM 1.5) and 25 other tissues See more
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Genomic context

See DLEU1 in Genome Data Viewer
Location:
13q14.2-q14.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (50082169..50528643)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (49302750..49743563)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50656305..51102779)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia 2 Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a Neighboring gene ribosomal protein L18 pseudogene 10 Neighboring gene uncharacterized LOC124900337 Neighboring gene ST13, Hsp70 interacting protein pseudogene 4 Neighboring gene LINE-1 retrotransposable element ORF2 protein-like Neighboring gene ribosomal protein L34 pseudogene 26 Neighboring gene DLEU1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 8262 Neighboring gene uncharacterized LOC107984568

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
EBI GWAS Catalog
Genome-wide association study of lung function decline in adults with and without asthma.
EBI GWAS Catalog
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
EBI GWAS Catalog
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • B-cell neoplasia-associated gene with multiple splicing
  • deleted in lymphocytic leukemia 1 (non-protein coding)
  • leukemia-associated protein 2
  • long intergenic non-protein coding RNA 21

Clone Names

  • FLJ92453, MGC22430

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002605.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL137060
    Related
    ENST00000655550.1
  2. NR_109973.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AJ412024, AK095311, AL137060, DB444728
    Related
    ENST00000469754.3
  3. NR_109974.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains multiple additional 3' terminal exons, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AJ412032, AJ412055, AL161424, DB444728
    Related
    ENST00000491615.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    50082169..50528643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    49302750..49743563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005887.1: Suppressed sequence

    Description
    NM_005887.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.