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DSCR4 Down syndrome critical region 4 [ Homo sapiens (human) ]

Gene ID: 10281, updated on 23-Nov-2021

Summary

Official Symbol
DSCR4provided by HGNC
Official Full Name
Down syndrome critical region 4provided by HGNC
Primary source
HGNC:HGNC:3045
See related
Ensembl:ENSG00000184029 MIM:604829
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCRB; DSCRB
Summary
The gene is found in a region of chromosome 21 that has been linked to the pathogenesis of Down syndrome. This gene is transcribed from a bi-directional promoter located in an endogenous retrovirus. [provided by RefSeq, Jan 2015]
Expression
Low expression observed in reference dataset See more
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Genomic context

See DSCR4 in Genome Data Viewer
Location:
21q22.13
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (38054011..38121360, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (39426313..39493454, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene potassium inwardly rectifying channel subfamily J member 6 Neighboring gene uncharacterized LOC101928368 Neighboring gene VISTA enhancer hs1811 Neighboring gene Sharpr-MPRA regulatory region 8394 Neighboring gene Down syndrome critical region 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • Down syndrome critical region gene 4
  • Down syndrome critical region protein 4
  • Down syndrome critical region protein B

Clone Names

  • AP001415.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_147130.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001410, AP001417, BU753721
    Related
    ENST00000328264.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    38054011..38121360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005867.3: Suppressed sequence

    Description
    NM_005867.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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