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PRR33 proline rich 33 [ Homo sapiens (human) ]

Gene ID: 102724536, updated on 2-Nov-2024

Summary

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Official Symbol
PRR33provided by HGNC
Official Full Name
proline rich 33provided by HGNC
Primary source
HGNC:HGNC:35118
See related
Ensembl:ENSG00000283787 AllianceGenome:HGNC:35118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf89
Summary
Predicted to act upstream of or within response to wounding. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See PRR33 in Genome Data Viewer
Location:
11p15.5
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1887987..1917708, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1973881..1981781, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1909308..1913125, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 4298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1891831-1892369 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1892370-1892907 Neighboring gene lymphocyte specific protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1896777-1897673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1897674-1898570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4294 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1908437-1908603 Neighboring gene microRNA 7847 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:1918050-1919249 Neighboring gene long intergenic non-protein coding RNA 1150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1927717-1928218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1928219-1928718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4295 Neighboring gene troponin T3, fast skeletal type Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1956346-1956534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1956988-1957585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1970491-1971228 Neighboring gene small nucleolar RNA, C/D box 131 Neighboring gene mitochondrial ribosomal protein L23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies novel breast cancer susceptibility loci. Easton DF, et al. Nature, 2007 Jun 28. PMID 17529967, Free PMC Article
  2. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Lindström S, et al. Nat Commun, 2014 Oct 24. PMID 25342443, Free PMC Article
  3. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Michailidou K, et al. Nat Genet, 2013 Apr. PMID 23535729, Free PMC Article
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
EBI GWAS Catalog
Genome-wide association study identifies novel breast cancer susceptibility loci.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Homology

General protein information

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Preferred Names
proline-rich protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395380.1 → NP_001382309.1  proline-rich protein 33

    Status: VALIDATED

    Source sequence(s)
    AC051649
    Consensus CDS
    CCDS91402.1
    UniProtKB/TrEMBL
    A0A1W2PPC1
    Related
    ENSP00000491327.1, ENST00000640310.2
    Conserved Domains (1) summary
    PRK12323
    Location:167 → 403
    PRK12323; DNA polymerase III subunit gamma/tau

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    1887987..1917708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426236.1 → XP_047282192.1  proline-rich protein 33 isoform X1

    UniProtKB/TrEMBL
    A0A1W2PPC1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160004.1 Reference GRCh38.p14 PATCHES

    Range
    78490..86565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332445.1 → XP_054188420.1  proline-rich protein 33 isoform X1

    UniProtKB/TrEMBL
    A0A1W2PPC1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    1973881..1981781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367441.1 → XP_054223416.1  proline-rich protein 33 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MZF0.2 GenPept UniProtKB/Swiss-Prot:A8MZF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials