LOC102724428 salt inducible kinase 1B (putative) [Homo sapiens (human)] - Gene

Summary

Gene symbol: LOC102724428
Gene description: salt inducible kinase 1B (putative)
See related: Ensembl:ENSG00000275993
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIK; SIK1; SIK-1; SIK1B; SNF1LK
Annotation information: Note: GeneID:102724428 is on a scaffold that is thought to be a false duplication and thus this gene is likely redundant with GeneID:150094. [11 Jun 2021]
Expression: Ubiquitous expression in adrenal (RPKM 33.0), liver (RPKM 26.8) and 25 other tissues See more
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Genomic context

Location:: 21p12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (6111131..6123778)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000021.9 Chromosome 21 Reference GRCh38.p14 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative serine/threonine-protein kinase SIK1B

Names: Salt-inducible kinase 1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK; probable serine/threonine-protein kinase SIK1B; salt-inducible kinase 1B; serine/threonine-protein kinase SIK1

NP_001307572.1

EC 2.7.11.1

XP_016883697.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320643.3 → NP_001307572.1 putative serine/threonine-protein kinase SIK1B

Status: VALIDATED

Source sequence(s)

AK131076, AW207331, BC038504, CU639417, HY023884

UniProtKB/Swiss-Prot

A0A0B4J2F2

Related

ENST00000613488.3

Conserved Domains (2) summary

cd14408
Location:300 → 349

UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)

cd14071
Location:26 → 278

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000021.9 Reference GRCh38.p14 Primary Assembly

Range

6111131..6123778

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017028208.2 → XP_016883697.1 putative serine/threonine-protein kinase SIK1B isoform X1

Conserved Domains (1) summary

cd14071
Location:26 → 278

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases