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FSTL3 follistatin like 3 [ Homo sapiens (human) ]

Gene ID: 10272, updated on 12-Oct-2019

Summary

Official Symbol
FSTL3provided by HGNC
Official Full Name
follistatin like 3provided by HGNC
Primary source
HGNC:HGNC:3973
See related
Ensembl:ENSG00000070404 MIM:605343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLRG; FSRP
Summary
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 92.4), testis (RPKM 32.9) and 13 other tissues See more
Orthologs

Genomic context

See FSTL3 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (676392..683385)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (676389..683392)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 22 Neighboring gene ring finger protein 126 Neighboring gene serine protease 57 Neighboring gene ribosomal protein S2 pseudogene 52 Neighboring gene paralemmin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Antagonism of Activin by Follistatin, organism-specific biosystem (from REACTOME)
    Antagonism of Activin by Follistatin, organism-specific biosystemBoth Follistatin (FST) and Follistatin-like-3 (FSTL3) irreversibly bind Activin dimers and prevent Activin from interacting with its receptor (reviewed in Schneyer et al. 2004 ,Xia and Schneyer 2009)...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Activin, organism-specific biosystem (from REACTOME)
    Signaling by Activin, organism-specific biosystemActivin was initially discovered as an activator of follicle stimulating hormone in the pituitary gland. It has since been shown to be an important participant in the differentiation of embryonic cel...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
activin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin binding IPI
Inferred from Physical Interaction
more info
PubMed 
fibronectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adrenal gland development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to metal ion IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection terminus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
follistatin-related protein 3
Names
follistatin-like 3 (secreted glycoprotein)
follistatin-like protein 3
follistatin-related gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005860.3NP_005851.1  follistatin-related protein 3 precursor

    See identical proteins and their annotated locations for NP_005851.1

    Status: REVIEWED

    Source sequence(s)
    AY358917, BX439786
    Consensus CDS
    CCDS12040.1
    UniProtKB/Swiss-Prot
    O95633
    UniProtKB/TrEMBL
    A0A024R1Y8
    Related
    ENSP00000166139.3, ENST00000166139.9
    Conserved Domains (2) summary
    smart00280
    Location:120167
    KAZAL; Kazal type serine protease inhibitors
    cl00097
    Location:171231
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    676392..683385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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