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CDK2AP2 cyclin dependent kinase 2 associated protein 2 [ Homo sapiens (human) ]

Gene ID: 10263, updated on 13-Mar-2020

Summary

Official Symbol
CDK2AP2provided by HGNC
Official Full Name
cyclin dependent kinase 2 associated protein 2provided by HGNC
Primary source
HGNC:HGNC:30833
See related
Ensembl:ENSG00000167797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p14; DOC-1R
Summary
This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in thyroid (RPKM 21.4), adrenal (RPKM 15.6) and 25 other tissues See more
Orthologs

Genomic context

See CDK2AP2 in Genome Data Viewer
Location:
11q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67506497..67508162, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67273961..67276199, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene aryl hydrocarbon receptor interacting protein Neighboring gene microRNA 6752 Neighboring gene phosphatidylinositol transfer protein membrane associated 1 Neighboring gene calcium binding protein 2 Neighboring gene glutathione S-transferase pi 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10636, FLJ98766

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 2-associated protein 2
Names
CDK2-associated protein 2
DOC-1-related protein
tumor suppressor deleted in oral cancer related 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271849.2NP_001258778.1  cyclin-dependent kinase 2-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001258778.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK310197, BQ016039, CB988039
    Conserved Domains (1) summary
    pfam09806
    Location:1870
    CDK2AP; Cyclin-dependent kinase 2-associated protein
  2. NM_005851.5NP_005842.1  cyclin-dependent kinase 2-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_005842.1

    Status: REVIEWED

    Source sequence(s)
    AP001184
    Consensus CDS
    CCDS8169.1
    UniProtKB/Swiss-Prot
    O75956
    UniProtKB/TrEMBL
    Q6IAV4
    Related
    ENSP00000301488.3, ENST00000301488.7
    Conserved Domains (2) summary
    pfam09806
    Location:73125
    CDK2AP; Cyclin-dependent kinase 2-associated protein
    cl28408
    Location:5106
    UBQ; Ubiquitin homologues

RNA

  1. NR_073484.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.
    Source sequence(s)
    BI763791, BM559572, BQ016039, CB988039

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67506497..67508162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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