Format

Send to:

Choose Destination

SPRY3 sprouty RTK signaling antagonist 3 [ Homo sapiens (human) ]

Gene ID: 10251, updated on 25-Nov-2021

Summary

Official Symbol
SPRY3provided by HGNC
Official Full Name
sprouty RTK signaling antagonist 3provided by HGNC
Primary source
HGNC:HGNC:11271
See related
Ensembl:ENSG00000168939 MIM:300531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
spry-3
Annotation information
Annotation category: partial on reference assembly
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SPRY3 in Genome Data Viewer
Location:
Xq28 and Yq12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (155612586..155782459)
109.20211119 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (56923423..56968979)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (154842247..155012121)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (59100403..59115127)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene int22h-3 recombination region Neighboring gene TMLHE antisense RNA 1 Neighboring gene H2A.B variant histone 3 Neighboring gene trimethyllysine hydroxylase, epsilon Neighboring gene meiotic recombination hotspot PAR2A Neighboring gene meiotic recombination hotspot PAR2 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 2 Neighboring gene diphthamide biosynthesis 3 pseudogene 2

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 4 pseudogene 1 Neighboring gene CCNQ pseudogene 2 Neighboring gene meiotic recombination hotspot PAR2A Neighboring gene meiotic recombination hotspot PAR2 Neighboring gene CTBP2 pseudogene 1 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 2 Neighboring gene diphthamide biosynthesis 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein sprouty homolog 3
Names
antagonist of FGF signaling
sprouty homolog 3
sprouty3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304990.2NP_001291919.1  protein sprouty homolog 3

    See identical proteins and their annotated locations for NP_001291919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. This variant is only expected to be expressed from the X chromosome. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
    Consensus CDS
    CCDS14769.4
    UniProtKB/Swiss-Prot
    O43610
    UniProtKB/TrEMBL
    Q6ZUP3
    Related
    ENSP00000502489.1, ENST00000675360.1
    Conserved Domains (1) summary
    pfam05210
    Location:152253
    Sprouty; Sprouty protein (Spry)
  2. NM_001394353.1NP_001381282.1  protein sprouty homolog 3

    Status: VALIDATED

    Source sequence(s)
    AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
    Conserved Domains (1) summary
    pfam05210
    Location:152253
    Sprouty; Sprouty protein (Spry)
  3. NM_001394354.1NP_001381283.1  protein sprouty homolog 3

    Status: VALIDATED

    Source sequence(s)
    AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
    Conserved Domains (1) summary
    pfam05210
    Location:152253
    Sprouty; Sprouty protein (Spry)
  4. NM_001394355.1NP_001381284.1  protein sprouty homolog 3

    Status: VALIDATED

    Source sequence(s)
    AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
    Conserved Domains (1) summary
    pfam05210
    Location:152253
    Sprouty; Sprouty protein (Spry)
  5. NM_005840.4NP_005831.1  protein sprouty homolog 3

    See identical proteins and their annotated locations for NP_005831.1

    Status: VALIDATED

    Source sequence(s)
    AJ271735, KC877980, KC877984, KC877988, KC877989, KF495814
    Consensus CDS
    CCDS14769.4
    UniProtKB/Swiss-Prot
    O43610
    UniProtKB/TrEMBL
    Q6ZUP3
    Related
    ENSP00000302978.2, ENST00000302805.7
    Conserved Domains (1) summary
    pfam05210
    Location:152253
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    155612586..155782459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    56923423..56968979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center