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Imp3 IMP3, U3 small nucleolar ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 102462, updated on 2-Nov-2024

Summary

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Official Symbol
Imp3provided by MGI
Official Full Name
IMP3, U3 small nucleolar ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:1916119
See related
Ensembl:ENSMUSG00000032288 AllianceGenome:MGI:1916119
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190002L16Rik
Summary
Predicted to enable snoRNA binding activity. Acts upstream of or within rRNA processing. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Mpp10 complex and small-subunit processome. Orthologous to human IMP3 (IMP U3 small nucleolar ribonucleoprotein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Imp3 in Genome Data Viewer
Location:
9 B; 9 30.53 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56844784..56845682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56937500..56938398)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56776219-56776328 Neighboring gene sorting nexin 33 Neighboring gene STARR-positive B cell enhancer ABC_E1386 Neighboring gene predicted gene, 19936 Neighboring gene STARR-positive B cell enhancer ABC_E3831 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56798396-56798654 Neighboring gene snurportin 1 Neighboring gene STARR-seq mESC enhancer starr_24215 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene predicted gene 10658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells. Ueki A, et al. PLoS One, 2012. PMID 23226335, Free PMC Article
  2. IMP3 promotes re-endothelialization after arterial injury via increasing stability of VEGF mRNAhv. Zhou X, et al. J Cell Mol Med, 2022 Apr. PMID 35315195, Free PMC Article
  3. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Granneman S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655004, Free PMC Article
  4. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Imp3 as a key regulator of stem-like tumorigenic characteristics in osteosarcoma cells
    Title: Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Mpp10 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mpp10 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of preribosome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
U3 small nucleolar ribonucleoprotein protein IMP3
Names
IMP3, U3 small nucleolar ribonucleoprotein, homolog
U3 snoRNP protein 3 homolog
U3 snoRNP protein IMP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133976.2 → NP_598737.1  U3 small nucleolar ribonucleoprotein protein IMP3

    See identical proteins and their annotated locations for NP_598737.1

    Status: PROVISIONAL

    Source sequence(s)
    BC009145
    Consensus CDS
    CCDS23213.1
    UniProtKB/Swiss-Prot
    Q921Y2
    Related
    ENSMUSP00000034827.9, ENSMUST00000034827.10
    Conserved Domains (2) summary
    COG0522
    Location:1 → 168
    RpsD; Ribosomal protein S4 or related protein [Translation, ribosomal structure and biogenesis]
    pfam01479
    Location:109 → 155
    S4; S4 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56844784..56845682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921Y2.1 GenPept UniProtKB/Swiss-Prot:Q921Y2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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