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SLC17A2 solute carrier family 17 member 2 [ Homo sapiens (human) ]

Gene ID: 10246, updated on 4-Jun-2020

Summary

Official Symbol
SLC17A2provided by HGNC
Official Full Name
solute carrier family 17 member 2provided by HGNC
Primary source
HGNC:HGNC:10930
See related
Ensembl:ENSG00000112337 MIM:611049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPT3
Expression
Restricted expression toward liver (RPKM 16.0) See more
Orthologs

Genomic context

See SLC17A2 in Genome Data Viewer
Location:
6p22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (25912754..25930727, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (25912982..25930954, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 3, pseudogene Neighboring gene H2B histone pseudogene 5 Neighboring gene CRISPRi-validated cis-regulatory element chr6.1077 Neighboring gene tripartite motif containing 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138238

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sialic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:phosphate symporter activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphate-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
sialic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
sodium-dependent phosphate transport protein 3
Names
Na(+)/PI cotransporter 3
sodium phosphate transporter 3
sodium/phosphate cotransporter 3
solute carrier family 17 (vesicular glutamate transporter), member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034000.1 RefSeqGene

    Range
    5036..22973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286123.3NP_001273052.1  sodium-dependent phosphate transport protein 3 isoform a

    See identical proteins and their annotated locations for NP_001273052.1

    Status: VALIDATED

    Source sequence(s)
    AL138726, U91328
    Consensus CDS
    CCDS69060.1
    UniProtKB/Swiss-Prot
    O00624
    Related
    ENSP00000367081.3, ENST00000377850.7
    Conserved Domains (2) summary
    cd06174
    Location:81461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:1477
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
  2. NM_001286125.2NP_001273054.1  sodium-dependent phosphate transport protein 3 isoform c

    See identical proteins and their annotated locations for NP_001273054.1

    Status: VALIDATED

    Source sequence(s)
    AL138726
    UniProtKB/Swiss-Prot
    O00624
    Conserved Domains (1) summary
    cd06174
    Location:81342
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. NM_005835.4NP_005826.1  sodium-dependent phosphate transport protein 3 isoform b

    See identical proteins and their annotated locations for NP_005826.1

    Status: VALIDATED

    Source sequence(s)
    BC104822, BJ993843, C21035, U90544
    Consensus CDS
    CCDS4567.1
    UniProtKB/Swiss-Prot
    O00624
    UniProtKB/TrEMBL
    A0A024QZY2
    Related
    ENSP00000353677.3, ENST00000360488.7
    Conserved Domains (1) summary
    cl27298
    Location:1354
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    25912754..25930727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714949.3XP_006715012.1  sodium-dependent phosphate transport protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006715012.1

    UniProtKB/Swiss-Prot
    O00624
    Related
    ENSP00000265425.3, ENST00000265425.3
    Conserved Domains (2) summary
    cd06174
    Location:81461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:1477
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
  2. XM_006714951.1XP_006715014.1  sodium-dependent phosphate transport protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006715014.1

    Conserved Domains (1) summary
    cd06174
    Location:81342
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. XM_006714950.2XP_006715013.1  sodium-dependent phosphate transport protein 3 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:58438
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:1454
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
  4. XM_017010159.1XP_016865648.1  sodium-dependent phosphate transport protein 3 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:58438
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:1454
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
  5. XM_017010160.1XP_016865649.1  sodium-dependent phosphate transport protein 3 isoform X4

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