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MFSD10 major facilitator superfamily domain containing 10 [ Homo sapiens (human) ]

Gene ID: 10227, updated on 1-Jun-2020

Summary

Official Symbol
MFSD10provided by HGNC
Official Full Name
major facilitator superfamily domain containing 10provided by HGNC
Primary source
HGNC:HGNC:16894
See related
Ensembl:ENSG00000109736 MIM:610977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TETRAN; TETTRAN
Summary
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 36.8), spleen (RPKM 13.5) and 24 other tissues See more
Orthologs

Genomic context

See MFSD10 in Genome Data Viewer
Location:
4p16.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (2930556..2934859, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2932288..2936586, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 125 enhancer Neighboring gene SH3 domain binding protein 2 Neighboring gene adducin 1 Neighboring gene NOP14 antisense RNA 1 Neighboring gene NOP14 nucleolar protein Neighboring gene G protein-coupled receptor kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
tetracycline transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
sodium-independent organic anion transport IDA
Inferred from Direct Assay
more info
PubMed 
tetracycline transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
major facilitator superfamily domain-containing protein 10
Names
tetracycline transporter-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001120.4NP_001111.3  major facilitator superfamily domain-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_001111.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AL390065, BC001502, BC023537, BI769550, L11669
    Consensus CDS
    CCDS3365.1
    UniProtKB/Swiss-Prot
    Q14728
    Related
    ENSP00000332646.4, ENST00000329687.8
    Conserved Domains (1) summary
    pfam07690
    Location:85412
    MFS_1; Major Facilitator Superfamily
  2. NM_001146069.2NP_001139541.1  major facilitator superfamily domain-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_001139541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC001502, CN422014
    Consensus CDS
    CCDS3365.1
    UniProtKB/Swiss-Prot
    Q14728
    Related
    ENSP00000347619.4, ENST00000355443.9
    Conserved Domains (1) summary
    pfam07690
    Location:85412
    MFS_1; Major Facilitator Superfamily
  3. NM_001363679.1NP_001350608.1  major facilitator superfamily domain-containing protein 10 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL390065
    Consensus CDS
    CCDS87203.1
    Related
    ENSP00000423402.1, ENST00000507555.1
    Conserved Domains (1) summary
    cl21472
    Location:90225
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    2930556..2934859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453871.1XP_024309639.1  major facilitator superfamily domain-containing protein 10 isoform X1

    Conserved Domains (2) summary
    pfam07690
    Location:85448
    MFS_1; Major Facilitator Superfamily
    cl21472
    Location:90225
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. XM_005247927.3XP_005247984.1  major facilitator superfamily domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    D6RE79
    Related
    ENSP00000426907.1, ENST00000514800.5
    Conserved Domains (2) summary
    cd06174
    Location:71416
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:85412
    MFS_1; Major Facilitator Superfamily

RNA

  1. XR_427465.3 RNA Sequence

    Related
    ENST00000503596.5
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