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Mtus1 mitochondrial tumor suppressor 1 [ Mus musculus (house mouse) ]

Gene ID: 102103, updated on 2-Nov-2024

Summary

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Official Symbol
Mtus1provided by MGI
Official Full Name
mitochondrial tumor suppressor 1provided by MGI
Primary source
MGI:MGI:2142572
See related
Ensembl:ENSMUSG00000045636 AllianceGenome:MGI:2142572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MD44; Atip1; MTSG1; ATBP135; mKIAA1288; Cctsg1-440; B430010I23Rik; B430305I03Rik
Summary
Predicted to enable microtubule binding activity. Acts upstream of or within regulation of macrophage chemotaxis. Located in cytoplasm. Is expressed in several structures, including extraembryonic component; eye; genitourinary system; heart; and nervous system. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 15.8), cerebellum adult (RPKM 12.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Mtus1 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41443949..41587318, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40990912..41133983, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Neighboring gene STARR-seq mESC enhancer starr_21277 Neighboring gene platelet-derived growth factor receptor-like Neighboring gene STARR-positive B cell enhancer ABC_E9310 Neighboring gene STARR-seq mESC enhancer starr_21279 Neighboring gene RIKEN cDNA B430010I23 gene Neighboring gene predicted gene 16193 Neighboring gene STARR-seq mESC enhancer starr_21283 Neighboring gene STARR-seq mESC enhancer starr_21286 Neighboring gene predicted gene, 39167 Neighboring gene STARR-seq mESC enhancer starr_21287 Neighboring gene fibrinogen-like protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Attenuation of cuff-induced neointimal formation by overexpression of angiotensin II type 2 receptor-interacting protein 1. Fujita T, et al. Hypertension, 2009 Apr. PMID 19221207
  2. Cardiovascular ATIP (Angiotensin receptor type 2 interacting protein) expression in mouse development. Bundschu K, et al. Dev Dyn, 2014 May. PMID 24288149
  3. Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization. Jing F, et al. PLoS One, 2013. PMID 23565185, Free PMC Article
  4. ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics. Molina A, et al. Cancer Res, 2013 May 1. PMID 23396587
  5. Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Wruck CJ, et al. Arterioscler Thromb Vasc Biol, 2005 Jan. PMID 15539617

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. important role in AT2 receptor-mediated PPARgamma activation
    Title: Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPARγ.
  2. ATIPs seem to be mainly involved in the developmental regulation of the cardiovascular system and may act in different AT2-dependent and -independent manners.
    Title: Cardiovascular ATIP (Angiotensin receptor type 2 interacting protein) expression in mouse development.
  3. ATIP1 could exert anti-inflammatory effects in adipose tissue via macrophage polarization associated with improvement of insulin resistance.
    Title: Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization.
  4. analysis of a functional ATIP3 domain that associates with microtubules and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration in breast cancer
    Title: ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics.
  5. Reports the first generation of a MTUS1 KO mouse, developing spontaneous heart hypertrophy and increased cell proliferation, confirming once more the anti-proliferative effect of MTUS1, and a SLE-like lymphoproliferative disease.
    Title: Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease.
  6. ATIP3 is a novel microtubule-associated protein related to MTUS1, with a role in invasiveness and progression of breast neoplasms
    Title: 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis.
  7. ATIP1 plays an important role in cuff-induced vascular remodeling in mice
    Title: Attenuation of cuff-induced neointimal formation by overexpression of angiotensin II type 2 receptor-interacting protein 1.
  8. Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade.
    Title: Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC115798

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of macrophage chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule-associated tumor suppressor 1 homolog
Names
AT2 receptor-binding protein
AT2 receptor-interacting protein 1
angiotensin II AT2 receptor-interacting protein 1
angiotensin-II type 2 receptor-interacting protein
coiled-coiled tumor suppressor gene 1 protein
coiled-coiled tumor supressor gene 1
mitochondrial tumor suppressor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005863.2 → NP_001005863.1  microtubule-associated tumor suppressor 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001005863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK143781, AW990620, BC089009
    Consensus CDS
    CCDS40328.1
    UniProtKB/Swiss-Prot
    Q3UP60, Q5HZI1, Q6ITD2, Q6ZPU5, Q80YG5, Q80YV9, Q80ZZ2, Q8BH23, Q8BMM8, Q8C0C8
    UniProtKB/TrEMBL
    A0A0R4J1L9
    Related
    ENSMUSP00000059503.7, ENSMUST00000059115.13
    Conserved Domains (1) summary
    TIGR02168
    Location:855 → 1155
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001005864.3 → NP_001005864.1  microtubule-associated tumor suppressor 1 homolog isoform 3

    See identical proteins and their annotated locations for NP_001005864.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in shorter protein (isoform 3) with a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BB647317, BC043321, DV650567
    Consensus CDS
    CCDS40329.1
    UniProtKB/TrEMBL
    A0A0R4J147
    Related
    ENSMUSP00000091252.5, ENSMUST00000093534.11
    Conserved Domains (2) summary
    pfam09755
    Location:193 → 460
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)
    cl19219
    Location:330 → 406
    DUF342; Protein of unknown function (DUF342)

  3. NM_001005865.4 → NP_001005865.2  microtubule-associated tumor suppressor 1 homolog isoform 4

    See identical proteins and their annotated locations for NP_001005865.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in shorter protein (isoform 4) with a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC116511
    Consensus CDS
    CCDS40330.1
    UniProtKB/TrEMBL
    A0A0R4J0N9
    Related
    ENSMUSP00000053554.8, ENSMUST00000051379.14
    Conserved Domains (1) summary
    cl19219
    Location:250 → 326
    DUF342; Protein of unknown function (DUF342)

  4. NM_001286413.2 → NP_001273342.1  microtubule-associated tumor suppressor 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001273342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AC116511, AC156554
    Consensus CDS
    CCDS40328.1
    UniProtKB/Swiss-Prot
    Q3UP60, Q5HZI1, Q6ITD2, Q6ZPU5, Q80YG5, Q80YV9, Q80ZZ2, Q8BH23, Q8BMM8, Q8C0C8
    UniProtKB/TrEMBL
    A0A0R4J1L9
    Related
    ENSMUSP00000112626.2, ENSMUST00000118835.8
    Conserved Domains (1) summary
    TIGR02168
    Location:855 → 1155
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. NM_001403946.1 → NP_001390875.1  microtubule-associated tumor suppressor 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116511, AC156554
    UniProtKB/TrEMBL
    A0A0R4J1L9

  6. NM_001403947.1 → NP_001390876.1  microtubule-associated tumor suppressor 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116511, AC156554
    UniProtKB/TrEMBL
    A0A0R4J1L9

  7. NM_001403950.1 → NP_001390879.1  microtubule-associated tumor suppressor 1 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116511, AC156554

  8. NM_001403952.1 → NP_001390881.1  microtubule-associated tumor suppressor 1 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116511, AC156554

  9. NM_001403954.1 → NP_001390883.1  microtubule-associated tumor suppressor 1 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC116511

  10. NM_001403955.1 → NP_001390884.1  microtubule-associated tumor suppressor 1 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC116511

  11. NM_001403956.1 → NP_001390885.1  microtubule-associated tumor suppressor 1 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC116511, AC156554
    UniProtKB/TrEMBL
    Q8BXV7
    Related
    ENSMUST00000142936.2

RNA

  1. NR_175785.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116511, AC156554

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41443949..41587318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509241.4 → XP_006509304.1  microtubule-associated tumor suppressor 1 homolog isoform X4

    Conserved Domains (1) summary
    TIGR02168
    Location:98 → 417
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_036153702.1 → XP_036009595.1  microtubule-associated tumor suppressor 1 homolog isoform X3

RNA

  1. XR_004934740.1 RNA Sequence

  2. XR_004934738.1 RNA Sequence

  3. XR_004934737.1 RNA Sequence

  4. XR_004934739.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZI1.2 GenPept UniProtKB/Swiss-Prot:Q5HZI1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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