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MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Ficedula albicollis (Collared flycatcher) ]

Gene ID: 101820743, updated on 8-Mar-2024

Summary

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Gene symbol
MTHFD1
Gene description
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
See related
Ensembl:ENSFALG00000003203
Gene type
protein coding
RefSeq status
MODEL
Organism
Ficedula albicollis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula
Orthologs
human mouse all
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Genomic context

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See MTHFD1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
28
Annotation release Status Assembly Chr Location
101 current FicAlb1.5 (GCF_000247815.1) 5 NC_021677.1 (57166095..57207208, complement)

Chromosome 5 - NC_021677.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene estrogen receptor 2 Neighboring gene spectrin repeat containing nuclear envelope protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_021677.1 Chromosome 5 Reference FicAlb1.5 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-1-tetrahydrofolate synthase, cytoplasmic

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ficedula albicollis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference FicAlb1.5 Primary Assembly

Genomic

  1. NC_021677.1 Reference FicAlb1.5 Primary Assembly

    Range
    57166095..57207208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005047703.2 → XP_005047760.1  C-1-tetrahydrofolate synthase, cytoplasmic

    UniProtKB/TrEMBL
    U3JKR6
    Related
    ENSFALP00000003370.1, ENSFALT00000003383.2
    Conserved Domains (4) summary
    cd01080
    Location:120 → 292
    NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:6 → 125
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Nucleotide Protein
Heading Accession and Version

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