U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Psip1 PC4 and SFRS1 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 101739, updated on 8-Feb-2024

Summary

Official Symbol
Psip1provided by MGI
Official Full Name
PC4 and SFRS1 interacting protein 1provided by MGI
Primary source
MGI:MGI:2142116
See related
Ensembl:ENSMUSG00000028484 AllianceGenome:MGI:2142116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dfs70; Psip2; Ledgfa; Ledgfb
Summary
Predicted to enable several functions, including chromatin binding activity; supercoiled DNA binding activity; and transcription coactivator activity. Involved in response to heat and response to oxidative stress. Predicted to be located in chromatin and nuclear lumen. Predicted to be active in nucleus. Is expressed in several structures, including cranial ganglion; limb; limb bud; sensory organ; and vibrissa. Orthologous to human PSIP1 (PC4 and SFRS1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 73.8), CNS E14 (RPKM 48.3) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Psip1 in Genome Data Viewer
Location:
4 C3; 4 39.46 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (83373917..83404700, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (83455680..83486463, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:82969964-82970265 Neighboring gene STARR-seq mESC enhancer starr_10639 Neighboring gene predicted gene, 42306 Neighboring gene predicted gene 11413 Neighboring gene predicted gene 11184 Neighboring gene STARR-seq mESC enhancer starr_10641 Neighboring gene STARR-positive B cell enhancer mm9_chr4:83063359-83063659 Neighboring gene small nuclear RNA activating complex, polypeptide 3 Neighboring gene STARR-seq mESC enhancer starr_10644 Neighboring gene ribosomal protein L34 pseudogene Neighboring gene predicted gene, 42308

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables supercoiled DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA 5'-splice site recognition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PC4 and SFRS1-interacting protein
Names
PC4 and SFRS1 interacting protein 2
dense fine speckles 70
lens epithelium-derived growth factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290527.2NP_001277456.1  PC4 and SFRS1-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_001277456.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' exon structure, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA177775, AI839843, AI843830, BC043079, BX682545, BY710824, CJ053610
    Consensus CDS
    CCDS71412.1
    UniProtKB/Swiss-Prot
    Q99JF8
    Related
    ENSMUSP00000102833.3, ENSMUST00000107215.9
    Conserved Domains (1) summary
    cd05834
    Location:387
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
  2. NM_001347143.2NP_001334072.1  PC4 and SFRS1-interacting protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA177775, BG076985, BM945511, BP766700, BX682545, CA328141, CK626008
    Consensus CDS
    CCDS84749.1
    UniProtKB/TrEMBL
    A2BI12
    Related
    ENSMUSP00000102832.3, ENSMUST00000107214.9
  3. NM_001355203.1NP_001342132.1  PC4 and SFRS1-interacting protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA177775, AI843830, BC043079, BX682545, BY710824, CD352945, CJ053610
    Conserved Domains (2) summary
    cd05834
    Location:387
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    cl26407
    Location:95245
    IF-2; Translation-initiation factor 2
  4. NM_133948.6NP_598709.1  PC4 and SFRS1-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_598709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC043079, BX682545, BY710824, CJ053610
    Consensus CDS
    CCDS18299.1
    UniProtKB/Swiss-Prot
    A2BI10, A2BI11, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99JF8, Q99LR4, Q9CT03
    Related
    ENSMUSP00000030207.9, ENSMUST00000030207.15
    Conserved Domains (2) summary
    cd05834
    Location:387
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:347448
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    83373917..83404700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)