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Pcsk5 proprotein convertase subtilisin/kexin type 5 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101711492, updated on 8-Mar-2024

Summary

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Gene symbol
Pcsk5
Gene description
proprotein convertase subtilisin/kexin type 5
See related
Ensembl:ENSHGLG00000000259
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
40
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624811.1 (3453218..3862970)

NW_004624811.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A protein-like 9 Neighboring gene uncharacterized LOC110345421 Neighboring gene nuclear receptor subfamily 5 group A member 2 pseudogene Neighboring gene uncharacterized LOC106010878 Neighboring gene uncharacterized LOC110345412 Neighboring gene 60S ribosomal protein L37a-like Neighboring gene riboflavin kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624811 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624811.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    3453218..3862970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004862529.2 → XP_004862586.1  proprotein convertase subtilisin/kexin type 5 isoform X3

    UniProtKB/TrEMBL
    G5BLA0
    Conserved Domains (9) summary
    cd04059
    Location:126 → 420
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:782 → 823
    FU; Furin-like repeats
    cd00064
    Location:1497 → 1544
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:162 → 445
    Peptidase_S8; Subtilase family
    pfam00757
    Location:988 → 1135
    Furin-like; Furin-like cysteine rich region
    pfam01483
    Location:505 → 595
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:1504 → 1612
    GF_recep_IV; Growth factor receptor domain IV
    pfam15913
    Location:1262 → 1394
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam16470
    Location:38 → 114
    S8_pro-domain; Peptidase S8 pro-domain

  2. XM_004862531.2 → XP_004862588.1  proprotein convertase subtilisin/kexin type 5 isoform X1

    Related
    ENSHGLP00000000255.1, ENSHGLT00000000289.1
    Conserved Domains (7) summary
    cd04059
    Location:126 → 420
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:782 → 823
    FU; Furin-like repeats
    cd00064
    Location:688 → 738
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:162 → 445
    Peptidase_S8; Subtilase family
    pfam01483
    Location:505 → 595
    P_proprotein; Proprotein convertase P-domain
    pfam08686
    Location:886 → 910
    PLAC; PLAC (protease and lacunin) domain
    pfam16470
    Location:38 → 114
    S8_pro-domain; Peptidase S8 pro-domain

  3. XM_021242737.1 → XP_021098396.1  proprotein convertase subtilisin/kexin type 5 isoform X2

    Conserved Domains (3) summary
    cd04059
    Location:126 → 420
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam16470
    Location:38 → 114
    S8_pro-domain; Peptidase S8 pro-domain
    cl27557
    Location:505 → 542
    P_proprotein; Proprotein convertase P-domain

RNA

  1. XR_002388733.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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