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Lrp6 LDL receptor related protein 6 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101703711, updated on 8-Mar-2024

Summary

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Gene symbol
Lrp6
Gene description
LDL receptor related protein 6
See related
Ensembl:ENSHGLG00000018784
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624752.1 (25605444..25756573)

NW_004624752.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain-containing protein 152 pseudogene Neighboring gene MANSC domain containing 1 Neighboring gene 26S protease regulatory subunit 10B pseudogene Neighboring gene coiled-coil domain-containing protein 152 pseudogene Neighboring gene BCL2 like 14 Neighboring gene uncharacterized protein C12orf45 pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624752 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Wnt receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis involved in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624752.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    25605444..25756573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004845872.2 → XP_004845929.1  low-density lipoprotein receptor-related protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A0P6JF39, G5BYG3
    Related
    ENSHGLP00000026400.1, ENSHGLT00000026636.1
    Conserved Domains (6) summary
    smart00135
    Location:483 → 524
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1288 → 1322
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:55 → 93
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:150 → 190
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:592 → 627
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:55 → 272
    NHL; NHL repeat unit of beta-propeller proteins

  2. XM_004845873.2 → XP_004845930.1  low-density lipoprotein receptor-related protein 6 isoform X2

    UniProtKB/TrEMBL
    G5BYG3
    Conserved Domains (6) summary
    smart00135
    Location:483 → 524
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1243 → 1277
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:55 → 93
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:150 → 190
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:592 → 627
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:55 → 272
    NHL; NHL repeat unit of beta-propeller proteins
Nucleotide Protein
Heading Accession and Version

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