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CEBPZ CCAAT enhancer binding protein zeta [ Homo sapiens (human) ]

Gene ID: 10153, updated on 5-Jul-2020

Summary

Official Symbol
CEBPZprovided by HGNC
Official Full Name
CCAAT enhancer binding protein zetaprovided by HGNC
Primary source
HGNC:HGNC:24218
See related
Ensembl:ENSG00000115816 MIM:612828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBF; CBF2; NOC1; HSP-CBF
Summary
This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]
Expression
Ubiquitous expression in testis (RPKM 27.1), adrenal (RPKM 18.8) and 25 other tissues See more
Orthologs

Genomic context

See CEBPZ in Genome Data Viewer
Location:
2p22.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (37201612..37231596, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37428772..37458740, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 2 Neighboring gene ARL14EP pseudogene 1 Neighboring gene sulfotransferase family 6B member 1 Neighboring gene ribosomal protein L31 pseudogene 16 Neighboring gene CEBPZ opposite strand Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene protein kinase D3 Neighboring gene uncharacterized LOC101929542

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CCAAT/enhancer-binding protein zeta
Names
CCAAT-box-binding transcription factor
CCAAT/enhancer binding protein (C/EBP), zeta
CCAAT/enhancer binding protein cebp family zeta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050962.1 RefSeqGene

    Range
    5002..34986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005760.3NP_005751.2  CCAAT/enhancer-binding protein zeta

    See identical proteins and their annotated locations for NP_005751.2

    Status: REVIEWED

    Source sequence(s)
    AC007390, BC034475
    Consensus CDS
    CCDS1787.1
    UniProtKB/Swiss-Prot
    Q03701
    Related
    ENSP00000234170.5, ENST00000234170.10
    Conserved Domains (3) summary
    COG5593
    Location:157988
    COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
    pfam03914
    Location:523731
    CBF; CBF/Mak21 family
    cl17018
    Location:273449
    FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    37201612..37231596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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