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CDH17 cadherin 17 [ Homo sapiens (human) ]

Gene ID: 1015, updated on 1-Aug-2020

Summary

Official Symbol
CDH17provided by HGNC
Official Full Name
cadherin 17provided by HGNC
Primary source
HGNC:HGNC:1756
See related
Ensembl:ENSG00000079112 MIM:603017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPT1; CDH16; HPT-1
Summary
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Expression
Biased expression in duodenum (RPKM 145.2), small intestine (RPKM 127.8) and 2 other tissues See more
Orthologs

Genomic context

See CDH17 in Genome Data Viewer
Location:
8q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (94127162..94217278, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95139394..95229531, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene proteasome subunit alpha 2 pseudogene 2 Neighboring gene ribosomal protein L34 pseudogene 18 Neighboring gene uncharacterized LOC105375647 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene uncharacterized LOC105375648 Neighboring gene GTP binding protein overexpressed in skeletal muscle

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26931, MGC138218, MGC142024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proton-dependent oligopeptide secondary active transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization TAS
Traceable Author Statement
more info
 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
germinal center B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
marginal zone B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
oligopeptide transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
oligopeptide transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of integrin activation by cell surface receptor linked signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
spleen development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cadherin-17
Names
HPT-1 cadherin
LI cadherin
cadherin 17, LI cadherin (liver-intestine)
cadherin-16
human intestinal peptide-associated transporter HPT-1
human peptide transporter 1
intestinal peptide-associated transporter HPT-1
liver-intestine cadherin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144663.2NP_001138135.1  cadherin-17 precursor

    See identical proteins and their annotated locations for NP_001138135.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK312873, AP003351, BF591263, U07969, X83228
    Consensus CDS
    CCDS6260.1
    UniProtKB/Swiss-Prot
    Q12864
    Related
    ENSP00000401468.2, ENST00000450165.6
    Conserved Domains (3) summary
    cd11304
    Location:570663
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:271338
    CA; Cadherin repeats
    cl09101
    Location:681765
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
  2. NM_004063.4NP_004054.3  cadherin-17 precursor

    See identical proteins and their annotated locations for NP_004054.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003351, BF591263, DB009107, U07969, X83228
    Consensus CDS
    CCDS6260.1
    UniProtKB/Swiss-Prot
    Q12864
    Related
    ENSP00000027335.3, ENST00000027335.8
    Conserved Domains (3) summary
    cd11304
    Location:570663
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:271338
    CA; Cadherin repeats
    cl09101
    Location:681765
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    94127162..94217278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516790.1XP_011515092.1  cadherin-17 isoform X1

    Conserved Domains (2) summary
    cd11304
    Location:570668
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:271338
    CA; Cadherin repeats
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