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ACTR1A actin related protein 1A [ Homo sapiens (human) ]

Gene ID: 10121, updated on 7-Jun-2020

Summary

Official Symbol
ACTR1Aprovided by HGNC
Official Full Name
actin related protein 1Aprovided by HGNC
Primary source
HGNC:HGNC:167
See related
Ensembl:ENSG00000138107 MIM:605143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP1; Arp1A; CTRN1
Summary
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 46.1), heart (RPKM 30.0) and 25 other tissues See more
Orthologs

Genomic context

See ACTR1A in Genome Data Viewer
Location:
10q24.32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (102479229..102502712, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104238986..104262580, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene microRNA 146b Neighboring gene RPARP antisense RNA 1 Neighboring gene chromosome 10 open reading frame 95 Neighboring gene major facilitator superfamily domain containing 13A Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene ribosomal protein L23a pseudogene 58 Neighboring gene RNA, U6 small nuclear 43, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ52695, FLJ52800, FLJ55002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
COPI-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
cell cortex region IDA
Inferred from Direct Assay
more info
PubMed 
centriole IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
manchette IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
alpha-centractin
Names
ARP1 actin related protein 1 homolog A
ARP1 actin-related protein 1 homolog A, centractin alpha
actin-RPV
centractin
centrosome-associated actin homolog
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011901.1 RefSeqGene

    Range
    5044..28527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005736.4NP_005727.1  alpha-centractin

    See identical proteins and their annotated locations for NP_005727.1

    Status: REVIEWED

    Source sequence(s)
    AL121928, BC000693, BC026016, DC384284
    Consensus CDS
    CCDS7536.1
    UniProtKB/Swiss-Prot
    P61163
    Related
    ENSP00000358921.4, ENST00000369905.9
    Conserved Domains (1) summary
    cl17037
    Location:5376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    102479229..102502712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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