Bmt2 base methyltransferase of 25S rRNA 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmt2provided by MGI
Official Full Name: base methyltransferase of 25S rRNA 2provided by MGI
Primary source: MGI:MGI:2141466
See related: Ensembl:ENSMUSG00000042742 AllianceGenome:MGI:2141466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B630005N14Rik
Summary: Predicted to enable S-adenosyl-L-methionine binding activity. Predicted to be involved in cellular response to amino acid starvation and negative regulation of TORC1 signaling. Predicted to act upstream of or within methylation. Predicted to be part of GATOR1 complex and KICSTOR complex. Orthologous to human BMT2 (base methyltransferase of 25S rRNA 2 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 4.8), whole brain E14.5 (RPKM 4.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 A1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (13625674..13677965, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (13625675..13677966, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI666701 (e-PCR)
- UniSTS:165451

NoName (e-PCR)
- UniSTS:487615

Homology

Homologs of the Bmt2 gene: The Bmt2 gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 498 organisms have orthologs with human gene Bmt2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GATOR1 complex	ISO Inferred from Sequence Orthology more info
part_of KICSTOR complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: S-adenosylmethionine sensor upstream of mTORC1

Names: UPF0532 protein C7orf60 homolog; probable methyltransferase BMT2 homolog; probable methyltransferase BTM2 homolog

NP_780521.2

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.