Format

Send to:

Choose Destination

ARPC3 actin related protein 2/3 complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 10094, updated on 7-Jun-2020

Summary

Official Symbol
ARPC3provided by HGNC
Official Full Name
actin related protein 2/3 complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:706
See related
Ensembl:ENSG00000111229 MIM:604225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC21; p21-Arc
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in lymph node (RPKM 232.8), bone marrow (RPKM 231.9) and 25 other tissues See more
Orthologs

Genomic context

See ARPC3 in Genome Data Viewer
Location:
12q24.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (110434823..110450411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110872695..110888222, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 7 Neighboring gene high mobility group AT-hook 1 pseudogene 3 Neighboring gene GPN-loop GTPase 3 Neighboring gene ribosomal protein L31 pseudogene 49 Neighboring gene family with sequence similarity 216 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin polymerization-dependent cell motility TAS
Traceable Author Statement
more info
PubMed 
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
filamentous actin IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
growth cone leading edge IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 3
Names
ARP2/3 protein complex subunit p21
actin related protein 2/3 complex, subunit 3, 21kDa
arp2/3 complex 21 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278556.2NP_001265485.1  actin-related protein 2/3 complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_001265485.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AC144548, AI144468, BC067747, BF434378
    Consensus CDS
    CCDS9146.1
    UniProtKB/Swiss-Prot
    O15145
    Related
    ENSP00000228825.7, ENST00000228825.12
    Conserved Domains (1) summary
    pfam04062
    Location:1173
    P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
  2. NM_001287222.1NP_001274151.1  actin-related protein 2/3 complex subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_001274151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting shorter isoform (2) lacks 1 aa compared to isoform 1.
    Source sequence(s)
    AI144468, BC078162, BF434378, BG620669
    UniProtKB/Swiss-Prot
    O15145
    Conserved Domains (1) summary
    pfam04062
    Location:1172
    P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    110434823..110450411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center