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ARPC5 actin related protein 2/3 complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 10092, updated on 17-Feb-2024

Summary

Official Symbol
ARPC5provided by HGNC
Official Full Name
actin related protein 2/3 complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:708
See related
Ensembl:ENSG00000162704 MIM:604227; AllianceGenome:HGNC:708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC16; IMD113; p16-Arc; dJ127C7.3
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in lymph node (RPKM 104.2), appendix (RPKM 91.8) and 25 other tissues See more
Orthologs
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Genomic context

See ARPC5 in Genome Data Viewer
Location:
1q25.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (183620846..183635783, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (182980128..182995065, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (183589981..183604918, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2214 Neighboring gene SMG7 nonsense mediated mRNA decay factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2215 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:183540266-183540431 Neighboring gene chromosome 18 open reading frame 32 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:183568525-183569024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2219 Neighboring gene Sharpr-MPRA regulatory region 11944 Neighboring gene neutrophil cytosolic factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2220 Neighboring gene NCF2-ARPC5 intergenic ENCODE-defined enhancer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:183604114-183604614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1635 Neighboring gene Sharpr-MPRA regulatory region 5056 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:183653331-183653832 Neighboring gene ral guanine nucleotide dissociation stimulator like 1 Neighboring gene T-box transcription factor T pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC88523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in focal adhesion HDA PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
located_in site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 5
Names
Arp2/3 protein complex subunit p16
actin related protein 2/3 complex, subunit 5, 16kDa
arp2/3 complex 16 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270439.2NP_001257368.1  actin-related protein 2/3 complex subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001257368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 2) is longer compared to isoform 1.
    Source sequence(s)
    AI148784, AL137800, BC057237, CN291383
    Consensus CDS
    CCDS58050.1
    UniProtKB/TrEMBL
    B1ALC0
    Related
    ENSP00000294742.6, ENST00000294742.6
    Conserved Domains (1) summary
    pfam04699
    Location:11151
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)
  2. NM_005717.4NP_005708.1  actin-related protein 2/3 complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_005708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AF006088, AI148784, AL137800, CN291383
    Consensus CDS
    CCDS1357.1
    UniProtKB/Swiss-Prot
    A6NEC4, O15511, Q6PG42
    UniProtKB/TrEMBL
    B1ALC0
    Related
    ENSP00000352918.6, ENST00000359856.11
    Conserved Domains (1) summary
    pfam04699
    Location:10149
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    183620846..183635783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    182980128..182995065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)