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ARPC5 actin related protein 2/3 complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 10092, updated on 7-Jun-2020

Summary

Official Symbol
ARPC5provided by HGNC
Official Full Name
actin related protein 2/3 complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:708
See related
Ensembl:ENSG00000162704 MIM:604227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC16; p16-Arc; dJ127C7.3
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in lymph node (RPKM 104.2), appendix (RPKM 91.8) and 25 other tissues See more
Orthologs

Genomic context

See ARPC5 in Genome Data Viewer
Location:
1q25.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (183620846..183635783, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (183595328..183605076, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985235 Neighboring gene Sharpr-MPRA regulatory region 11944 Neighboring gene NCF2-ARPC5 intergenic ENCODE-defined enhancer Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Neighboring gene ral guanine nucleotide dissociation stimulator like 1 Neighboring gene T-box transcription factor T pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
actin filament network formation IEA
Inferred from Electronic Annotation
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
lamellipodium organization IEA
Inferred from Electronic Annotation
more info
 
maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
microtubule organizing center localization IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
orbitofrontal cortex development IEA
Inferred from Electronic Annotation
more info
 
smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 5
Names
Arp2/3 protein complex subunit p16
actin related protein 2/3 complex, subunit 5, 16kDa
arp2/3 complex 16 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270439.2NP_001257368.1  actin-related protein 2/3 complex subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001257368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 2) is longer compared to isoform 1.
    Source sequence(s)
    AI148784, AL137800, BC057237, CN291383
    Consensus CDS
    CCDS58050.1
    UniProtKB/Swiss-Prot
    O15511
    Related
    ENSP00000294742.6, ENST00000294742.6
    Conserved Domains (1) summary
    pfam04699
    Location:10152
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)
  2. NM_005717.4NP_005708.1  actin-related protein 2/3 complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_005708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AF006088, AI148784, AL137800, CN291383
    Consensus CDS
    CCDS1357.1
    UniProtKB/Swiss-Prot
    O15511
    Related
    ENSP00000352918.6, ENST00000359856.11
    Conserved Domains (1) summary
    pfam04699
    Location:11148
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    183620846..183635783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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