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HSPA1A heat shock 70kDa protein 1A [ Ovis aries (sheep) ]

Gene ID: 100913152, updated on 7-Feb-2024

Summary

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Gene symbol
HSPA1A
Gene description
heat shock 70kDa protein 1A
See related
EnsemblRapid:ENSOARG00020032141
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
HSP70; Hsp-70
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Genomic context

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Location:
chromosome: 20
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 20 NC_056073.1 (26604033..26605958, complement)

Chromosome 20 - NC_056073.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import inner membrane translocase subunit Tim17-B-like Neighboring gene small nucleolar RNA SNORD48 Neighboring gene heat shock 70 kDa protein 1B Neighboring gene heat shock protein family A (Hsp70) member 1 like Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene valyl-tRNA synthetase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056073.1 Chromosome 20 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs. Afolayan AJ, et al. Am J Physiol Lung Cell Mol Physiol, 2014 Feb 15. PMID 24375796, Free PMC Article
  2. The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs. Gulbahar MY, et al. J Vet Sci, 2011 Mar. PMID 21368565, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inducible HSP70 chaperones SOD-2 to the mitochondria in the endothelial cells from developing lungs. [iHSP70]
    Title: Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs.
  2. The results of this study show that the anti-apoptotic proteins, HSP70 and alpha-BC, were overexpressed with increased apoptosis in foot-and-mouth disease virus-infected heart tissues.[HSP70]
    Title: The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
Submit: New GeneRIF Correction

General gene information

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Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables misfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chaperone cofactor-dependent protein refolding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
heat shock 70 kDa protein 1A/1B
Names
heat shock 70 kDa protein
heat shock protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267874.1 → NP_001254803.1  heat shock 70 kDa protein 1A/1B

    See identical proteins and their annotated locations for NP_001254803.1

    Status: PROVISIONAL

    Source sequence(s)
    JN604434
    UniProtKB/TrEMBL
    A0A6P3CXE7, A0A836CTK6, H2DGR2
    Related
    ENSOARP00020049406.1, ENSOART00020075857.1
    Conserved Domains (2) summary
    cd10233
    Location:6 → 381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1 → 641
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056073.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    26604033..26605958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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