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KCNK7 potassium two pore domain channel subfamily K member 7 [ Homo sapiens (human) ]

Gene ID: 10089, updated on 7-Jun-2020

Summary

Official Symbol
KCNK7provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 7provided by HGNC
Primary source
HGNC:HGNC:6282
See related
Ensembl:ENSG00000173338 MIM:603940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TWIK3; K2p7.1
Summary
This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 11.7), esophagus (RPKM 2.1) and 1 other tissue See more
Orthologs

Genomic context

See KCNK7 in Genome Data Viewer
Location:
11q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65592836..65595800, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65360326..65363467, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 89 member B Neighboring gene EH domain binding protein 1 like 1 Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene pecanex 3 Neighboring gene microRNA 4690

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118782, MGC118784

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 7
Names
potassium channel, subfamily K, member 7
potassium channel, two pore domain subfamily K, member 7
two pore domain K+ channel

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005714.2NP_005705.1  potassium channel subfamily K member 7 isoform C precursor

    See identical proteins and their annotated locations for NP_005705.1

    Status: REVIEWED

    Source sequence(s)
    AP001362
    Consensus CDS
    CCDS41673.1
    UniProtKB/Swiss-Prot
    Q9Y2U2
    UniProtKB/TrEMBL
    A0A024R5F5
    Related
    ENSP00000377764.2, ENST00000394216.6
    Conserved Domains (2) summary
    TIGR02551
    Location:36195
    SpaO_YscQ; type III secretion system apparatus protein YscQ/HrcQ
    pfam07885
    Location:90140
    Ion_trans_2; Ion channel
  2. NM_033347.2NP_203133.1  potassium channel subfamily K member 7 isoform A precursor

    See identical proteins and their annotated locations for NP_203133.1

    Status: REVIEWED

    Source sequence(s)
    AP001362
    Consensus CDS
    CCDS31608.1
    UniProtKB/Swiss-Prot
    Q9Y2U2
    Related
    ENSP00000344820.4, ENST00000340313.4
    Conserved Domains (1) summary
    pfam07885
    Location:90140
    Ion_trans_2; Ion channel
  3. NM_033348.2NP_203134.1  potassium channel subfamily K member 7 isoform B precursor

    See identical proteins and their annotated locations for NP_203134.1

    Status: REVIEWED

    Source sequence(s)
    AP001362
    Consensus CDS
    CCDS8106.1
    UniProtKB/Swiss-Prot
    Q9Y2U2
    UniProtKB/TrEMBL
    A0A024R5B0
    Related
    ENSP00000377765.2, ENST00000394217.6
    Conserved Domains (1) summary
    pfam07885
    Location:90140
    Ion_trans_2; Ion channel
  4. NM_033455.2NP_258416.1  potassium channel subfamily K member 7 isoform B precursor

    See identical proteins and their annotated locations for NP_258416.1

    Status: REVIEWED

    Source sequence(s)
    AP001362
    Consensus CDS
    CCDS8106.1
    UniProtKB/Swiss-Prot
    Q9Y2U2
    UniProtKB/TrEMBL
    A0A024R5B0, Q3SYI1
    Related
    ENSP00000343923.4, ENST00000342202.8
    Conserved Domains (1) summary
    pfam07885
    Location:90140
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65592836..65595800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033456.1: Suppressed sequence

    Description
    NM_033456.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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