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TSPAN32 tetraspanin 32 [ Homo sapiens (human) ]

Gene ID: 10077, updated on 1-Aug-2020

Summary

Official Symbol
TSPAN32provided by HGNC
Official Full Name
tetraspanin 32provided by HGNC
Primary source
HGNC:HGNC:13410
See related
Ensembl:ENSG00000064201 MIM:603853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ART1; PHMX; PHEMX; TSSC6
Summary
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 10.4), spleen (RPKM 4.1) and 5 other tissues See more
Orthologs

Genomic context

See TSPAN32 in Genome Data Viewer
Location:
11p15.5
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (2299480..2318204)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2323195..2339430)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 4686 Neighboring gene tyrosine hydroxylase Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene chromosome 11 open reading frame 21 Neighboring gene RNA, U6 small nuclear 878, pseudogene Neighboring gene CD81 antisense RNA 1 Neighboring gene ribosomal protein L26 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog

General gene information

Markers

  • D11S1318 (e-PCR), detects polymorphism

Homology

Clone Names

  • FLJ17158, FLJ97586, MGC22455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
defense response to protozoan IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid dendritic cell activation IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin alphaIIb-beta3 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetraspanin-32
Names
pan-hematopoietic expression protein
protein Phemx
tumor-suppressing STF cDNA 6
tumor-suppressing subchromosomal transferable fragment cDNA 6
tumor-suppressing subtransferable candidate 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139022.3NP_620591.3  tetraspanin-32

    See identical proteins and their annotated locations for NP_620591.3

    Status: REVIEWED

    Source sequence(s)
    AA701395, AC129929, AY039001, BG506933
    Consensus CDS
    CCDS7733.1
    UniProtKB/Swiss-Prot
    Q96QS1
    Related
    ENSP00000182290.4, ENST00000182290.8
    Conserved Domains (2) summary
    cd03153
    Location:113195
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:11223
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    2299480..2318204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017067.1XP_016872556.1  tetraspanin-32 isoform X7

    Conserved Domains (2) summary
    cd03153
    Location:83165
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:36193
    Tetraspannin; Tetraspanin family
  2. XM_005252719.4XP_005252776.1  tetraspanin-32 isoform X2

    Conserved Domains (2) summary
    cd03153
    Location:148230
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:46258
    Tetraspannin; Tetraspanin family
  3. XM_011519822.1XP_011518124.1  tetraspanin-32 isoform X10

    Related
    ENSP00000370513.3, ENST00000381121.7
    Conserved Domains (2) summary
    cd03153
    Location:148230
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:46258
    Tetraspannin; Tetraspanin family
  4. XM_005252720.4XP_005252777.1  tetraspanin-32 isoform X11

    Conserved Domains (2) summary
    cd03153
    Location:148217
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:46196
    Tetraspannin; Tetraspanin family
  5. XM_011519829.3XP_011518131.2  tetraspanin-32 isoform X13

  6. XM_011519819.1XP_011518121.1  tetraspanin-32 isoform X7

    Conserved Domains (2) summary
    cd03153
    Location:83165
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:36193
    Tetraspannin; Tetraspanin family
  7. XM_011519815.3XP_011518117.3  tetraspanin-32 isoform X5

    Conserved Domains (1) summary
    cd03153
    Location:93170
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  8. XM_011519818.3XP_011518120.3  tetraspanin-32 isoform X6

    Related
    ENSP00000482901.1, ENST00000612299.4
    Conserved Domains (1) summary
    cd03153
    Location:93170
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  9. XM_017017064.1XP_016872553.1  tetraspanin-32 isoform X1

    Conserved Domains (1) summary
    cd03153
    Location:171248
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  10. XM_017017065.1XP_016872554.1  tetraspanin-32 isoform X3

  11. XM_017017068.1XP_016872557.1  tetraspanin-32 isoform X8

  12. XM_017017066.1XP_016872555.1  tetraspanin-32 isoform X4

  13. XM_017017069.1XP_016872558.1  tetraspanin-32 isoform X9

  14. XM_017017071.1XP_016872560.1  tetraspanin-32 isoform X12

RNA

  1. XR_001747714.1 RNA Sequence

  2. XR_001747715.1 RNA Sequence

  3. XR_001747716.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005705.4: Suppressed sequence

    Description
    NM_005705.4: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_139024.3: Suppressed sequence

    Description
    NM_139024.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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