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PCAT1 prostate cancer associated transcript 1 [ Homo sapiens (human) ]

Gene ID: 100750225, updated on 9-Jan-2022

Summary

Official Symbol
PCAT1provided by HGNC
Official Full Name
prostate cancer associated transcript 1provided by HGNC
Primary source
HGNC:HGNC:43022
See related
Ensembl:ENSG00000253438 MIM:616043
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCA1; PiHL; PCAT-1
Summary
This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways. [provided by RefSeq, Dec 2017]
Expression
Low expression observed in reference dataset See more
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Genomic context

See PCAT1 in Genome Data Viewer
Location:
8q24.21
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (127013154..127021014)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128025399..128033259)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375751 Neighboring gene RNA, U11 small nuclear 4, pseudogene Neighboring gene uncharacterized LOC105375753 Neighboring gene serine/arginine repetitive matrix 1 pseudogene 1 Neighboring gene prostate cancer associated non-coding RNA 1 Neighboring gene prostate cancer associated transcript 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • p53 inhibiting lncRNA
  • prostate cancer associated transcript 1 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_045262.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067843
    Related
    ENST00000561978.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    127013154..127021014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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