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Psph phosphoserine phosphatase [ Mus musculus (house mouse) ]

Gene ID: 100678, updated on 2-Nov-2024

Summary

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Official Symbol
Psphprovided by MGI
Official Full Name
phosphoserine phosphataseprovided by MGI
Primary source
MGI:MGI:97788
See related
Ensembl:ENSMUSG00000029446 AllianceGenome:MGI:97788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSP; PSPase
Summary
Predicted to enable L-phosphoserine phosphatase activity; magnesium ion binding activity; and protein homodimerization activity. Acts upstream of or within in utero embryonic development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; liver; and urinary system. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 14.8), liver E14 (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Psph in Genome Data Viewer
Location:
5 G1.3; 5 68.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129842622..129864318, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129765558..129787443, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11303 Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:130230774-130230883 Neighboring gene nipsnap homolog 2 Neighboring gene STARR-seq mESC enhancer starr_14458 Neighboring gene STARR-seq mESC enhancer starr_14459 Neighboring gene STARR-positive B cell enhancer ABC_E854 Neighboring gene predicted gene, 23245 Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene small nucleolar RNA, H/ACA box 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Augmented Mitochondrial Transfer Involved in Astrocytic PSPH Attenuates Cognitive Dysfunction in db/db Mice. Ma H, et al. Mol Neurobiol, 2024 Nov. PMID 38573412
  2. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Nakano I, et al. Stem Cells, 2007 Aug. PMID 17495110
  3. Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Meehan TF, et al. Nat Genet, 2017 Aug. PMID 28650483, Free PMC Article
  4. ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH. Wang T, et al. Mol Ther, 2023 Mar 1. PMID 36639869, Free PMC Article
  5. L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis. Bachelor MA, et al. J Dermatol Sci, 2011 Sep. PMID 21726982, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Augmented Mitochondrial Transfer Involved in Astrocytic PSPH Attenuates Cognitive Dysfunction in db/db Mice.
    Title: Augmented Mitochondrial Transfer Involved in Astrocytic PSPH Attenuates Cognitive Dysfunction in db/db Mice.
  2. ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH.
    Title: ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH.
  3. status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation
    Title: L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis.
  4. PSP has a role in neural stem cell proliferation and may regulate signaling between neural stem cells and other cells within the stem cell niche.
    Title: Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-phosphoserine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-phosphoserine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables L-phosphoserine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-serine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-serine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-serine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-serine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
  
involved_in response to testosterone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoserine phosphatase
Names
O-phosphoserine phosphohydrolase
NP_598661.1
XP_006504337.1
XP_006504338.1
XP_017176063.1
XP_030109871.1
XP_030109872.1
XP_030109873.1
XP_036020582.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133900.4 → NP_598661.1  phosphoserine phosphatase

    See identical proteins and their annotated locations for NP_598661.1

    Status: VALIDATED

    Source sequence(s)
    AA003039, AI841354, BQ177662, BY125431, BY127546, CV560928
    Consensus CDS
    CCDS19699.1
    UniProtKB/Swiss-Prot
    Q3TI16, Q5XHW3, Q99LS3
    Related
    ENSMUSP00000031399.7, ENSMUST00000031399.13
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129842622..129864318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504274.5 → XP_006504337.1  phosphoserine phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006504337.1

    UniProtKB/Swiss-Prot
    Q3TI16, Q5XHW3, Q99LS3
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  2. XM_030254011.1 → XP_030109871.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    Q3TI16, Q5XHW3, Q99LS3
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  3. XM_036164689.1 → XP_036020582.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    Q3TI16, Q5XHW3, Q99LS3
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  4. XM_030254012.2 → XP_030109872.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    Q3TI16, Q5XHW3, Q99LS3
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  5. XM_030254013.2 → XP_030109873.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    Q3TI16, Q5XHW3, Q99LS3
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  6. XM_017320574.1 → XP_017176063.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    Q3TI16, Q5XHW3, Q99LS3
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  7. XM_006504275.4 → XP_006504338.1  phosphoserine phosphatase isoform X2

    Conserved Domains (1) summary
    cd04309
    Location:1 → 165
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LS3.1 GenPept UniProtKB/Swiss-Prot:Q99LS3

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