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Kifc1 kinesin family member C1 [ Mus musculus (house mouse) ]

Gene ID: 100502766, updated on 5-Nov-2022

Summary

Official Symbol
Kifc1provided by MGI
Official Full Name
kinesin family member C1provided by MGI
Primary source
MGI:MGI:109596
See related
Ensembl:ENSMUSG00000079553 AllianceGenome:MGI:109596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HSET; KNSL2; Gm4137; Kifc5a; Knsl2a; Tctex7; Tctex-7; Tctex7a; Tctex-7A; 100042970
Summary
Enables minus-end-directed microtubule motor activity. Acts upstream of or within minus-end-directed vesicle transport along microtubule and negative regulation of centrosome duplication. Located in endocytic vesicle; nucleus; and spindle. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 30.2), liver E14.5 (RPKM 27.2) and 17 other tissues See more
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Genomic context

See Kifc1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34094638..34109607, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33875664..33890633, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52316 Neighboring gene uncharacterized LOC118568329 Neighboring gene small integral membrane protein 40, pseudogene Neighboring gene microRNA 6967-2 Neighboring gene small integral membrane protein 40 Neighboring gene cDNA sequence BC051226

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Kifc1 gene: The Kifc1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Clone Names

  • MGC5880, MGC67832, MGC117605

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables minus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of kinesin complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIFC1
Names
kinesin family c-terminal 5A
kinesin motor protein KIFC4
kinesin-like 2a
kinesin-related protein KIFC5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195298.1NP_001182227.1  kinesin-like protein KIFC1 isoform 1

    See identical proteins and their annotated locations for NP_001182227.1

    Status: VALIDATED

    Source sequence(s)
    AI322653, AI326799, AK133900, CX205646, CX209658
    Consensus CDS
    CCDS57065.1
    UniProtKB/Swiss-Prot
    Q9JKZ0, Q9QWT9
    Related
    ENSMUSP00000134572.2, ENSMUST00000173492.9
    Conserved Domains (4) summary
    smart00129
    Location:311667
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:309666
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam15233
    Location:171300
    SYCE1; Synaptonemal complex central element protein 1
    pfam15619
    Location:146306
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
  2. NM_001410585.1NP_001397514.1  kinesin-like protein KIFC1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT030732
  3. NM_001410586.1NP_001397515.1  kinesin-like protein KIFC1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT030732
  4. NM_001410587.1NP_001397516.1  kinesin-like protein KIFC1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT030732
  5. NM_001410588.1NP_001397517.1  kinesin-like protein KIFC1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT030732

RNA

  1. NR_177090.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT030732

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34094638..34109607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246227.4XP_011244529.1  kinesin-like protein KIFC1 isoform X1

    Conserved Domains (1) summary
    cd01366
    Location:14371
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins