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SAP25 Sin3A associated protein 25 [ Homo sapiens (human) ]

Gene ID: 100316904, updated on 19-Aug-2025
Official Symbol
SAP25provided by HGNC
Official Full Name
Sin3A associated protein 25provided by HGNC
Primary source
HGNC:HGNC:41908
See related
Ensembl:ENSG00000205307 MIM:619230; AllianceGenome:HGNC:41908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in spleen (RPKM 17.5), lymph node (RPKM 8.4) and 20 other tissues See more
Orthologs
mouse all
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See SAP25 in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100572228..100573900, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101812311..101813983, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100169851..100171523, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901708 Neighboring gene ArfGAP with FG repeats 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100166771-100167442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100168785-100169455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100172387-100172941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100172942-100173495 Neighboring gene insulin receptor substrate 3, pseudogene Neighboring gene leucine rich repeats and calponin homology domain containing 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100181227-100181915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100182061-100182574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100182575-100183088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100187581-100188381 Neighboring gene PCOLCE antisense RNA 1 Neighboring gene F-box protein 24

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Distinct Regions within SAP25 Recruit O-Linked Glycosylation, DNA Demethylation, and Ubiquitin Ligase and Hydrolase Activities to the Sin3/HDAC Complex. Goswami P, et al. J Proteome Res, 2024 Nov 1. PMID 39435885, Free PMC Article
  2. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. Shiio Y, et al. Mol Cell Biol, 2006 Feb. PMID 16449650, Free PMC Article
  3. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107411
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct Regions within SAP25 Recruit O-Linked Glycosylation, DNA Demethylation, and Ubiquitin Ligase and Hydrolase Activities to the Sin3/HDAC Complex.
    Title: Distinct Regions within SAP25 Recruit O-Linked Glycosylation, DNA Demethylation, and Ubiquitin Ligase and Hydrolase Activities to the Sin3/HDAC Complex.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
histone deacetylase complex subunit SAP25
Names
25 kDa Sin3-associated polypeptide
Sin3 corepressor complex subunit SAP25
Sin3A-associated protein, 25kDa
sin3-associated polypeptide, 25kDa
sin3A-binding protein 25

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168682.3 → NP_001162153.2  histone deacetylase complex subunit SAP25 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC069281, BQ635892, BX117305, CR976678
    Conserved Domains (1) summary
    pfam15476
    Location:92 → 290
    SAP25; Histone deacetylase complex subunit SAP25

  2. NM_001348677.2 → NP_001335606.1  histone deacetylase complex subunit SAP25 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains an intron in the 5' end compared to variant 1. The resulting isoform (3)is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC069281
    Consensus CDS
    CCDS55137.1
    UniProtKB/Swiss-Prot
    Q8TEE9
    Related
    ENSP00000481351.1, ENST00000614631.4
    Conserved Domains (1) summary
    pfam15476
    Location:1 → 199
    SAP25; Histone deacetylase complex subunit SAP25

  3. NM_001348680.2 → NP_001335609.1  histone deacetylase complex subunit SAP25 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC069281
    Consensus CDS
    CCDS87529.1
    UniProtKB/TrEMBL
    A0A087WYF9
    Related
    ENSP00000481773.2, ENST00000622764.3
    Conserved Domains (1) summary
    pfam15476
    Location:99 → 297
    SAP25; Histone deacetylase complex subunit SAP25

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100572228..100573900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101812311..101813983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001348670.1: Suppressed sequence

    Description
    NM_001348670.1: This RefSeq was removed because of a processing error.

  2. NM_001348671.1: Suppressed sequence

    Description
    NM_001348671.1: This RefSeq was removed because of a processing error.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TEE9.2 GenPept UniProtKB/Swiss-Prot:Q8TEE9

Gene LinkOut

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