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SAP25 Sin3A associated protein 25 [ Homo sapiens (human) ]

Gene ID: 100316904, updated on 18-Aug-2020

Summary

Official Symbol
SAP25provided by HGNC
Official Full Name
Sin3A associated protein 25provided by HGNC
Primary source
HGNC:HGNC:41908
See related
Ensembl:ENSG00000205307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in spleen (RPKM 17.5), lymph node (RPKM 8.4) and 20 other tissues See more
Orthologs

Genomic context

See SAP25 in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100572228..100573900, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100169851..100171487, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ArfGAP with FG repeats 2 Neighboring gene insulin receptor substrate 3, pseudogene Neighboring gene leucine rich repeats and calponin homology domain containing 4 Neighboring gene ZO-2 associated speckle protein Neighboring gene F-box protein 24 Neighboring gene PCOLCE antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone deacetylase complex subunit SAP25
Names
25 kDa Sin3-associated polypeptide
Sin3 corepressor complex subunit SAP25
Sin3A-associated protein, 25kDa
sin3-associated polypeptide, 25kDa
sin3A-binding protein 25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168682.3NP_001162153.2  histone deacetylase complex subunit SAP25 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC069281, BQ635892, BX117305, CR976678
    Conserved Domains (1) summary
    pfam15476
    Location:92290
    SAP25; Histone deacetylase complex subunit SAP25
  2. NM_001348677.2NP_001335606.1  histone deacetylase complex subunit SAP25 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains an intron in the 5' end compared to variant 1. The resulting isoform (3)is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC069281
    Consensus CDS
    CCDS55137.1
    UniProtKB/Swiss-Prot
    Q8TEE9
    Related
    ENSP00000481351.1, ENST00000614631.4
    Conserved Domains (1) summary
    pfam15476
    Location:1199
    SAP25; Histone deacetylase complex subunit SAP25
  3. NM_001348680.2NP_001335609.1  histone deacetylase complex subunit SAP25 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC069281
    Consensus CDS
    CCDS87529.1
    UniProtKB/TrEMBL
    A0A087WYF9
    Related
    ENSP00000481773.2, ENST00000622764.3
    Conserved Domains (1) summary
    pfam15476
    Location:99297
    SAP25; Histone deacetylase complex subunit SAP25

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100572228..100573900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001348670.1: Suppressed sequence

    Description
    NM_001348670.1: This RefSeq was removed because of a processing error.
  2. NM_001348671.1: Suppressed sequence

    Description
    NM_001348671.1: This RefSeq was removed because of a processing error.
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