SEMA6D semaphorin 6D [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: SEMA6D
Gene description: semaphorin 6D
Locus tag: CR201_G0020082
See related: Ensembl:ENSPPYG00000006450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	16	NC_072001.2 (50092101..50680842)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	15	NC_072000.1 (47371762..47960504)

Chromosome 16 - NC_072001.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

G09531 (e-PCR)
- UniSTS:21053

D15S123 (e-PCR), detects polymorphism
- UniSTS:13933

D15S666 (e-PCR)
- UniSTS:54165

D15S1188 (e-PCR)
- UniSTS:50075

SEMA6D_1632 (e-PCR)
- UniSTS:277703

AB063027 (e-PCR)
- UniSTS:479956

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemorepellent activity	IEA Inferred from Electronic Annotation more info	PubMed
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: semaphorin-6D

Names: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001132877.2 → NP_001126349.1 semaphorin-6D precursor

See identical proteins and their annotated locations for NP_001126349.1

Status: PROVISIONAL

Source sequence(s)

CR860163

UniProtKB/Swiss-Prot

Q5R7F5

Related

ENSPPYP00000007307.3, ENSPPYT00000007609.3

Conserved Domains (2) summary

cd11269
Location:49 → 513

Sema_6D; The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D)

pfam01437
Location:514 → 569

PSI; Plexin repeat

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_072001.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

50092101..50680842

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054531128.2 → XP_054387103.1 semaphorin-6D isoform X1
XM_054531135.2 → XP_054387110.1 semaphorin-6D isoform X3
XM_054531139.2 → XP_054387114.1 semaphorin-6D isoform X7

UniProtKB/TrEMBL

A0A2J8VB66, A0A8I5UVV0
XM_054531129.2 → XP_054387104.1 semaphorin-6D isoform X1
XM_054531130.2 → XP_054387105.1 semaphorin-6D isoform X1
XM_054531132.2 → XP_054387107.1 semaphorin-6D isoform X1
XM_054531133.2 → XP_054387108.1 semaphorin-6D isoform X2

UniProtKB/TrEMBL

A0A2J8VB69, A0A8I5TG85
XM_054531131.2 → XP_054387106.1 semaphorin-6D isoform X1
XM_054531127.2 → XP_054387102.1 semaphorin-6D isoform X1
XM_063716037.1 → XP_063572107.1 semaphorin-6D isoform X5
XM_063716036.1 → XP_063572106.1 semaphorin-6D isoform X4
XM_024232180.3 → XP_024087948.1 semaphorin-6D isoform X1

Conserved Domains (3) summary

cd11269
Location:49 → 513

Sema_6D; The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D)

pfam01437
Location:514 → 543

PSI; Plexin repeat

cl25496
Location:944 → 1080

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_054531140.2 → XP_054387115.1 semaphorin-6D isoform X7

UniProtKB/TrEMBL

A0A2J8VB66, A0A8I5UVV0
XM_054531134.2 → XP_054387109.1 semaphorin-6D isoform X2

UniProtKB/TrEMBL

A0A2J8VB69, A0A8I5TG85
XM_054531138.2 → XP_054387113.1 semaphorin-6D isoform X6

UniProtKB/TrEMBL

A0A2J8VB76, H2NN54
XM_054531141.2 → XP_054387116.1 semaphorin-6D isoform X8

UniProtKB/TrEMBL

A0A2J8VB85
XM_054531136.2 → XP_054387111.1 semaphorin-6D isoform X4