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Pafah2 platelet-activating factor acetylhydrolase 2 [ Mus musculus (house mouse) ]

Gene ID: 100163, updated on 2-Nov-2024

Summary

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Official Symbol
Pafah2provided by MGI
Official Full Name
platelet-activating factor acetylhydrolase 2provided by MGI
Primary source
MGI:MGI:2140321
See related
Ensembl:ENSMUSG00000037366 AllianceGenome:MGI:2140321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310074E22Rik
Summary
Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity and platelet-activating factor acetyltransferase activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm. Is expressed in alimentary system; nervous system; and respiratory system. Orthologous to human PAFAH2 (platelet activating factor acetylhydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver adult (RPKM 25.3), kidney adult (RPKM 24.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pafah2 in Genome Data Viewer
Location:
4 D2.3; 4 66.68 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134123631..134154723)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134396320..134427412)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 (zinc transporter), member 2 Neighboring gene exostosin-like glycosyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_11675 Neighboring gene STARR-positive B cell enhancer ABC_E3526 Neighboring gene STARR-seq mESC enhancer starr_11677 Neighboring gene predicted gene, 30453 Neighboring gene RIKEN cDNA 1700021N21 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. Kono N, et al. J Biol Chem, 2008 Jan 18. PMID 18024956
  2. Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling. Moriyama H, et al. Nat Commun, 2022 May 31. PMID 35641514, Free PMC Article
  3. Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation. Shimanaka Y, et al. Nat Med, 2017 Nov. PMID 29035365
  4. Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice. Prows DR, et al. Physiol Genomics, 2007 Aug 20. PMID 17488888
  5. Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Taketomi Y, et al. Immunity, 2024 Aug 13. PMID 39002541

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F(2alpha) and protects tissue from oxidative stress-induced injury.
    Title: Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables platelet-activating factor acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables platelet-activating factor acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
platelet-activating factor acetylhydrolase 2, cytoplasmic
Names
PAF:lysophospholipid transacetylase
PAF:sphingosine transacetylase
SD-PLA2
platelet-activating factor acetyltransferase PAFAH2
serine-dependent phospholipase A2
NP_001272801.1
NP_001272803.1
NP_001272804.1
NP_001272806.1
NP_598641.2
XP_006538518.1
XP_011248473.1
XP_017175376.1
XP_030108914.1
XP_036019430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285872.1 → NP_001272801.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY233826
    Consensus CDS
    CCDS71490.1
    UniProtKB/TrEMBL
    E9QNW6, Q3U0K4
    Related
    ENSMUSP00000101496.2, ENSMUST00000105870.8
    Conserved Domains (1) summary
    pfam03403
    Location:26 → 404
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  2. NM_001285874.1 → NP_001272803.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b

    See identical proteins and their annotated locations for NP_001272803.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY233826
    Consensus CDS
    CCDS18771.1
    UniProtKB/Swiss-Prot
    E9QNW7, Q8R0Y7, Q8VDG7
    UniProtKB/TrEMBL
    Q3U0K4
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  3. NM_001285875.1 → NP_001272804.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform c

    See identical proteins and their annotated locations for NP_001272804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY032695, BY233826, BY782149
    Conserved Domains (1) summary
    cl21494
    Location:1 → 259
    Abhydrolase; alpha/beta hydrolases

  4. NM_001285877.1 → NP_001272806.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform c

    See identical proteins and their annotated locations for NP_001272806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three exons in the 5' region and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY233826
    Conserved Domains (1) summary
    cl21494
    Location:1 → 259
    Abhydrolase; alpha/beta hydrolases

  5. NM_133880.3 → NP_598641.2  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b

    See identical proteins and their annotated locations for NP_598641.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY032695, BY233826, BY782149
    Consensus CDS
    CCDS18771.1
    UniProtKB/Swiss-Prot
    E9QNW7, Q8R0Y7, Q8VDG7
    UniProtKB/TrEMBL
    Q3U0K4
    Related
    ENSMUSP00000101495.3, ENSMUST00000105869.9
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134123631..134154723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250171.3 → XP_011248473.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_011248473.1

    UniProtKB/Swiss-Prot
    E9QNW7, Q8R0Y7, Q8VDG7
    UniProtKB/TrEMBL
    Q3U0K4
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  2. XM_017319887.2 → XP_017175376.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    E9QNW7, Q8R0Y7, Q8VDG7
    UniProtKB/TrEMBL
    Q3U0K4
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  3. XM_036163537.1 → XP_036019430.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    E9QNW7, Q8R0Y7, Q8VDG7
    UniProtKB/TrEMBL
    Q3U0K4
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  4. XM_006538455.3 → XP_006538518.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006538518.1

    UniProtKB/Swiss-Prot
    E9QNW7, Q8R0Y7, Q8VDG7
    UniProtKB/TrEMBL
    Q3U0K4
    Conserved Domains (1) summary
    pfam03403
    Location:1 → 379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  5. XM_030253054.1 → XP_030108914.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X2

    Conserved Domains (1) summary
    cl21494
    Location:1 → 259
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDG7.2 GenPept UniProtKB/Swiss-Prot:Q8VDG7

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