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Pafah2 platelet-activating factor acetylhydrolase 2 [ Mus musculus (house mouse) ]

Gene ID: 100163, updated on 27-Sep-2022

Summary

Official Symbol
Pafah2provided by MGI
Official Full Name
platelet-activating factor acetylhydrolase 2provided by MGI
Primary source
MGI:MGI:2140321
See related
Ensembl:ENSMUSG00000037366 AllianceGenome:MGI:2140321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310074E22Rik
Summary
Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity and platelet-activating factor acetyltransferase activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in alimentary system; nervous system; and respiratory system. Orthologous to human PAFAH2 (platelet activating factor acetylhydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 25.3), kidney adult (RPKM 24.7) and 27 other tissues See more
Orthologs
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Genomic context

See Pafah2 in Genome Data Viewer
Location:
4; 4 D2.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134123631..134154723)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134396320..134427412)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 (zinc transporter), member 2 Neighboring gene exostosin-like glycosyltransferase 1 Neighboring gene predicted gene, 30453 Neighboring gene RIKEN cDNA 1700021N21 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables platelet-activating factor acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
platelet-activating factor acetylhydrolase 2, cytoplasmic
Names
PAF:lysophospholipid transacetylase
PAF:sphingosine transacetylase
SD-PLA2
platelet-activating factor acetyltransferase PAFAH2
serine-dependent phospholipase A2
NP_001272801.1
NP_001272803.1
NP_001272804.1
NP_001272806.1
NP_598641.2
XP_006538518.1
XP_011248473.1
XP_017175376.1
XP_030108914.1
XP_036019430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285872.1NP_001272801.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY233826
    Consensus CDS
    CCDS71490.1
    UniProtKB/TrEMBL
    E9QNW6
    Related
    ENSMUSP00000101496.2, ENSMUST00000105870.8
    Conserved Domains (1) summary
    pfam03403
    Location:26404
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
  2. NM_001285874.1NP_001272803.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b

    See identical proteins and their annotated locations for NP_001272803.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY233826
    Consensus CDS
    CCDS18771.1
    UniProtKB/Swiss-Prot
    Q8R0Y7, Q8VDG7
    Conserved Domains (1) summary
    pfam03403
    Location:1379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
  3. NM_001285875.1NP_001272804.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform c

    See identical proteins and their annotated locations for NP_001272804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY032695, BY233826, BY782149
    Conserved Domains (1) summary
    cl21494
    Location:1259
    Abhydrolase; alpha/beta hydrolases
  4. NM_001285877.1NP_001272806.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform c

    See identical proteins and their annotated locations for NP_001272806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three exons in the 5' region and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY233826
    Conserved Domains (1) summary
    cl21494
    Location:1259
    Abhydrolase; alpha/beta hydrolases
  5. NM_133880.3NP_598641.2  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b

    See identical proteins and their annotated locations for NP_598641.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AI846306, AK075918, AL669982, BQ179290, BY032695, BY233826, BY782149
    Consensus CDS
    CCDS18771.1
    UniProtKB/Swiss-Prot
    Q8R0Y7, Q8VDG7
    Related
    ENSMUSP00000101495.3, ENSMUST00000105869.9
    Conserved Domains (1) summary
    pfam03403
    Location:1379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134123631..134154723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250171.3XP_011248473.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_011248473.1

    UniProtKB/Swiss-Prot
    Q8R0Y7, Q8VDG7
    Conserved Domains (1) summary
    pfam03403
    Location:1379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
  2. XM_017319887.2XP_017175376.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    Q8R0Y7, Q8VDG7
    Conserved Domains (1) summary
    pfam03403
    Location:1379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
  3. XM_036163537.1XP_036019430.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    Q8R0Y7
    Conserved Domains (1) summary
    pfam03403
    Location:1379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
  4. XM_006538455.3XP_006538518.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006538518.1

    UniProtKB/Swiss-Prot
    Q8R0Y7, Q8VDG7
    Conserved Domains (1) summary
    pfam03403
    Location:1379
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
  5. XM_030253054.1XP_030108914.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X2

    Conserved Domains (1) summary
    cl21494
    Location:1259
    Abhydrolase; alpha/beta hydrolases