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KDM6A lysine demethylase 6A [ Sus scrofa (pig) ]

Gene ID: 100154376, updated on 8-Mar-2024

Summary

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Gene symbol
KDM6A
Gene description
lysine demethylase 6A
See related
Ensembl:ENSSSCG00000012262
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in lung (RPKM 10.2), kidney (RPKM 9.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See KDM6A in Genome Data Viewer
Location:
chromosome: X
Exon count:
30
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) X NC_010461.5 (39953764..40154197)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) X NC_010461.4 (44504617..44704755)

Chromosome X - NC_010461.5Genomic Context describing neighboring genes Neighboring gene FUN14 domain containing 1 Neighboring gene dual specificity phosphatase 21 Neighboring gene divergent protein kinase domain 2B Neighboring gene tripartite motif-containing protein 60-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K27me2/H3K27me3 demethylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lysine-specific demethylase 6A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010461.5 Reference Sscrofa11.1 Primary Assembly

    Range
    39953764..40154197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021079778.1 → XP_020935437.1  lysine-specific demethylase 6A isoform X1

    UniProtKB/TrEMBL
    A0A5G2RCQ6, A0A8D1L0L3
    Related
    ENSSSCP00000074206.2, ENSSSCT00000076509.2
    Conserved Domains (5) summary
    pfam02373
    Location:1186 → 1294
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1152 → 1216
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl25496
    Location:650 → 946
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. XM_021079779.1 → XP_020935438.1  lysine-specific demethylase 6A isoform X2

    UniProtKB/TrEMBL
    A0A5G2RCQ6, A0A8D1L0L3
    Conserved Domains (5) summary
    pfam02373
    Location:1152 → 1260
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1118 → 1182
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl25496
    Location:616 → 912
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  3. XM_021079782.1 → XP_020935441.1  lysine-specific demethylase 6A isoform X5

    UniProtKB/TrEMBL
    A0A481CAK5, K7GQT0
    Related
    ENSSSCP00000030254.4, ENSSSCT00000034832.4
    Conserved Domains (5) summary
    pfam02373
    Location:1100 → 1208
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1066 → 1130
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl25496
    Location:564 → 860
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  4. XM_021079780.1 → XP_020935439.1  lysine-specific demethylase 6A isoform X3

    UniProtKB/TrEMBL
    A0A480KQY0, A0A8D1ESM4
    Related
    ENSSSCP00000030340.4, ENSSSCT00000035863.4
    Conserved Domains (5) summary
    pfam02373
    Location:1141 → 1249
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1107 → 1171
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 401
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl25496
    Location:605 → 901
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  5. XM_021079783.1 → XP_020935442.1  lysine-specific demethylase 6A isoform X6

    UniProtKB/TrEMBL
    A0A8D1I5C0
    Conserved Domains (6) summary
    pfam02373
    Location:1089 → 1197
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1055 → 1119
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:47 → 315
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl25496
    Location:553 → 849
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28296
    Location:269 → 372
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]

  6. XM_021079784.1 → XP_020935443.1  lysine-specific demethylase 6A isoform X7

    UniProtKB/TrEMBL
    A0A8D1I5C0
    Conserved Domains (6) summary
    pfam02373
    Location:1055 → 1163
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1021 → 1085
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:47 → 315
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl25496
    Location:519 → 815
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28296
    Location:269 → 372
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]

  7. XM_021079781.1 → XP_020935440.1  lysine-specific demethylase 6A isoform X4

    UniProtKB/TrEMBL
    A0A480F432, A0A8D0W6S9
    Related
    ENSSSCP00000066092.2, ENSSSCT00000084190.2
    Conserved Domains (5) summary
    pfam02373
    Location:1134 → 1242
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1100 → 1164
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl25496
    Location:598 → 894
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RNA

  1. XR_002340583.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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