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steap2 STEAP family member 2, metalloreductase [ Danio rerio (zebrafish) ]

Gene ID: 100151287, updated on 17-Sep-2024

Summary

Official Symbol
steap2provided by ZNC
Official Full Name
STEAP family member 2, metalloreductaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-131121-79
See related
Ensembl:ENSDARG00000062887 AllianceGenome:ZFIN:ZDB-GENE-131121-79
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable cupric reductase activity and ferric-chelate reductase (NADPH) activity. Predicted to be involved in copper ion import. Predicted to act upstream of or within ion transport and iron ion homeostasis. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP2 (STEAP2 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
chromosome: 24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (31831421..31846301, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (31897116..31909221, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489262 Neighboring gene uncharacterized LOC137489261 Neighboring gene uncharacterized LOC100535932 Neighboring gene deltex E3 ubiquitin ligase 3L a Neighboring gene complement component 1, q subcomponent-like 3a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cupric reductase (NADH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within iron ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
metalloreductase STEAP2
Names
six transmembrane epithelial antigen of the prostate 2
XP_001921185.1
XP_068073343.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    31831421..31846301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001921150.6XP_001921185.1  metalloreductase STEAP2 isoform X2

    UniProtKB/TrEMBL
    A0A8M1QQW0, E7FFL9
    Related
    ENSDARP00000127717.1, ENSDART00000155295.2
    Conserved Domains (3) summary
    COG2085
    Location:33227
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:265408
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:37122
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
  2. XM_068217242.1XP_068073343.1  metalloreductase STEAP2 isoform X1