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arhgef40 Rho guanine nucleotide exchange factor (GEF) 40 [ Danio rerio (zebrafish) ]

Gene ID: 100151026, updated on 12-Sep-2024

Summary

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Official Symbol
arhgef40provided by ZNC
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 40provided by ZNC
Primary source
ZFIN:ZDB-GENE-110623-2
See related
Ensembl:ENSDARG00000078979 AllianceGenome:ZFIN:ZDB-GENE-110623-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human ARHGEF40 (Rho guanine nucleotide exchange factor 40). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 7
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (73488072..73578401)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (73265974..73349299)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108190819 Neighboring gene uncharacterized LOC137496247 Neighboring gene zinc finger protein 219 Neighboring gene bloodthirsty-related gene family, member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish. Atienzar-Aroca R, et al. Int J Mol Sci, 2022 Sep 1. PMID 36077382, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 40
Names
pleckstrin homology domain-containing family G member 4B
zmp:0000001199

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    73488072..73578401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001919569.8 → XP_001919604.4  rho guanine nucleotide exchange factor 40

    UniProtKB/TrEMBL
    A0A8M1QUP4, E7F579
    Related
    ENSDARP00000099409.2, ENSDART00000110330.4
    Conserved Domains (3) summary
    pfam00169
    Location:1562 → 1661
    PH; PH domain
    cl02571
    Location:1381 → 1519
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:1534 → 1673
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version

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