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SUPT20HL1 SUPT20H like 1 [ Homo sapiens (human) ]

Gene ID: 100130302, updated on 2-Nov-2024

Summary

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Official Symbol
SUPT20HL1provided by HGNC
Official Full Name
SUPT20H like 1provided by HGNC
Primary source
HGNC:HGNC:30773
See related
Ensembl:ENSG00000223731 AllianceGenome:HGNC:30773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPT20L; FAM48B1
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of SAGA complex. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See SUPT20HL1 in Genome Data Viewer
Location:
Xp22.11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (24360639..24367839)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (23944797..23952006)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24378756..24385956)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29499 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24167489-24168302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29500 Neighboring gene ZFX antisense RNA 1 Neighboring gene zinc finger protein X-linked Neighboring gene CRISPRi-validated cis-regulatory element chrX.477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24328768-24329520 Neighboring gene SUPT20H like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24382719-24383459 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:24389623-24390398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24394111-24394637 Neighboring gene NANOG hESC enhancer GRCh37_chrX:24428490-24429048 Neighboring gene ribosomal protein S26 pseudogene 58 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20719 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24509351-24510314 Neighboring gene pyruvate dehydrogenase kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29505 Neighboring gene SNRPE pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Nagy Z, et al. Mol Cell Biol, 2009 Mar. PMID 19114550, Free PMC Article
  2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor SPT20 homolog-like 1
Names
SPT20 homolog, SAGA complex component like 1
family with sequence similarity 48, member B1
suppressor of Ty 20 homolog-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136234.3 → NP_001129706.3  transcription factor SPT20 homolog-like 1

    Status: VALIDATED

    Source sequence(s)
    AC004552
    Consensus CDS
    CCDS94581.1
    UniProtKB/Swiss-Prot
    Q3ZLR7
    UniProtKB/TrEMBL
    A0A7I2YQ69
    Related
    ENSP00000509731.1, ENST00000686983.1
    Conserved Domains (2) summary
    PHA03247
    Location:381 → 764
    PHA03247; large tegument protein UL36; Provisional
    pfam12090
    Location:64 → 217
    Spt20; Spt20 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    24360639..24367839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    23944797..23952006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ZLR7.2 GenPept UniProtKB/Swiss-Prot:Q3ZLR7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials