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MIR450B microRNA 450b [ Homo sapiens (human) ]

Gene ID: 100126302, updated on 10-Dec-2019

Summary

Official Symbol
MIR450Bprovided by HGNC
Official Full Name
microRNA 450bprovided by HGNC
Primary source
HGNC:HGNC:33642
See related
Ensembl:ENSG00000216001 miRBase:MI0005531
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN450B; mir-450b
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

See MIR450B in Genome Data Viewer
Location:
Xq26.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (134540185..134540262, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133674215..133674292, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene origin of replication in promoter/intron 1 of HPRT1 Neighboring gene hypoxanthine phosphoribosyltransferase 1 Neighboring gene ribosomal protein L36a pseudogene 54 Neighboring gene microRNA 450a-1 Neighboring gene microRNA 450a-2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • miRNAs involved in DNA damage response, organism-specific biosystem (from WikiPathways)
    miRNAs involved in DNA damage response, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_030587.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC004383
    Related
    ENST00000401182.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    134540185..134540262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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