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Cstdc6 cystatin domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 100038854, updated on 8-Feb-2024

Summary

Official Symbol
Cstdc6provided by MGI
Official Full Name
cystatin domain containing 6provided by MGI
Primary source
MGI:MGI:3696881
See related
Ensembl:ENSMUSG00000079594 AllianceGenome:MGI:3696881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1975
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular components, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 138.5), liver E14 (RPKM 27.5) and 1 other tissue See more
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Genomic context

See Cstdc6 in Genome Data Viewer
Location:
16 B3; 16 25.47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36142027..36154694, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36321665..36334332, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene cystatin domain containing 3 Neighboring gene predicted gene, 24437 Neighboring gene cystatin domain containing 5 Neighboring gene predicted gene, 24218

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • MGC151441, MGC151467

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide cross-linking ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cornified envelope ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of peptidase inhibitor complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001332.2NP_001001332.2  stefin A1-like protein

    See identical proteins and their annotated locations for NP_001001332.2

    Status: VALIDATED

    Source sequence(s)
    CT033776
    Consensus CDS
    CCDS49840.1
    UniProtKB/TrEMBL
    L7N257, Q8CGL5
    Related
    ENSMUSP00000110500.3, ENSMUST00000114850.3
    Conserved Domains (1) summary
    pfam00031
    Location:390
    Cystatin; Cystatin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36142027..36154694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)