ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: ATP2A1
Gene description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
See related: Ensembl:ENSOCUG00000002688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as: ATP2A3; SERCA1a
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	6	NC_067379.1 (18715353..18734172)

Chromosome 6 - NC_067379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067379.1 Chromosome 6 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angle change of the A-domain in a single SERCA1a molecule detected by defocused orientation imaging.
Title: Angle change of the A-domain in a single SERCA1a molecule detected by defocused orientation imaging.
These findings provide a quantitative basis for SERCA1a function that leverages molecular-scale thermodynamic data and rationalizes enzyme activity across broad ranges of K(+), Ca(2+), and Mg(2+) concentrations.
Title: Thermodynamics of Cation Binding to the Sarcoendoplasmic Reticulum Calcium ATPase Pump and Impacts on Enzyme Function.
Phospholamban (PLB) oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase (SERCA) binding were quantified by fluorescence resonance energy transfer (FRET) in an intact cellular environment.
Title: Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells.
interactions between the cytoplasmic domain of phospholamban and negatively charged phospholipids might play a role in moderating the regulation of SERCA, with implications for cardiac muscle contractility.
Title: Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?
functional studies and three new crystal structures of the rabbit skeletal muscle Ca2+-ATPase.
Title: The structural basis of calcium transport by the calcium pump.
Protonation of the Ca(2+) ligands of the SR Ca(2+)-ATPase (SERCA1a) was studied by a combination of rapid scan FTIR spectroscopy and electrostatic calculations.
Title: Protonation and hydrogen bonding of Ca2+ site residues in the E2P phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase studied by a combination of infrared spectroscopy and electrostatic calculations.
the major SR membrane lipid PC is optimal for all steps and, unlike the other headgroups, contributes favorable electrostatics and non-electrostatic elements during the Ca-ATPase transition
Title: Nanodisc-based kinetic assays reveal distinct effects of phospholipid headgroups on the phosphoenzyme transition of sarcoplasmic reticulum Ca(2+)-ATPase.
ATP-dependent Ca(2+) transport by SERCA in single giant unilamellar vesicles was detected directly using confocal fluorescence microscopy.
Title: Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.
Glycine 105 as Pivot for a Critical Knee-like Joint between Cytoplasmic and Transmembrane Segments of the Second Transmembrane Helix in Ca2+-ATPase.(
Title: Glycine 105 as Pivot for a Critical Knee-like Joint between Cytoplasmic and Transmembrane Segments of the Second Transmembrane Helix in Ca2+-ATPase.
Here we describe the methods to analyze these processes in the transport cycle with a representative member of P-type ATPase family, SERCA1a, sarco(endo)plasmic reticulum Ca(2+)-ATPase
Title: Phosphorylation/Dephosphorylation Assays.

Submit: New GeneRIF Correction See all GeneRIFs (33)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Names: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; ATPase, Ca++ transporting, ubiquitous; SERCA1; SR Ca(2+)-ATPase 1; calcium pump 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase

NP_001082787.1

EC 7.2.2.10

XP_051703343.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089318.1 → NP_001082787.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 1

See identical proteins and their annotated locations for NP_001082787.1

Status: PROVISIONAL

Source sequence(s)

M12898

UniProtKB/Swiss-Prot

P04191, P11719

UniProtKB/TrEMBL

G1SI34

Related

ENSOCUP00000002327.4, ENSOCUT00000002689.4

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3