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ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100037716, updated on 5-Sep-2025
Gene symbol
ATP2A1
Gene description
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
See related
Ensembl:ENSOCUG00000002688
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
ATP2A3; SERCA1a
Orthologs
human mouse all
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See ATP2A1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 19 NC_091450.1 (7716129..7732446)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 6 NC_067379.1 (18715353..18734172)

Chromosome 19 - NC_091450.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC138847129 Neighboring gene SH2B adaptor protein 1 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene CD19 molecule Neighboring gene nuclear factor of activated T cells 2 interacting protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Thermodynamics of Cation Binding to the Sarcoendoplasmic Reticulum Calcium ATPase Pump and Impacts on Enzyme Function. Sun B, et al. J Chem Theory Comput, 2019 Apr 9. PMID 30807147, Free PMC Article
  2. Protonation and hydrogen bonding of Ca2+ site residues in the E2P phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase studied by a combination of infrared spectroscopy and electrostatic calculations. Andersson J, et al. Biophys J, 2008 Jan 15. PMID 17890386, Free PMC Article
  3. Conformational fluctuations of the Ca2+-ATPase in the native membrane environment. Effects of pH, temperature, catalytic substrates, and thapsigargin. Inesi G, et al. J Biol Chem, 2008 Jan 11. PMID 17993458
  4. The structural basis of calcium transport by the calcium pump. Olesen C, et al. Nature, 2007 Dec 13. PMID 18075584
  5. Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling? Hughes E, et al. Biochim Biophys Acta, 2009 Feb. PMID 19059204

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Angle change of the A-domain in a single SERCA1a molecule detected by defocused orientation imaging.
    Title: Angle change of the A-domain in a single SERCA1a molecule detected by defocused orientation imaging.
  2. These findings provide a quantitative basis for SERCA1a function that leverages molecular-scale thermodynamic data and rationalizes enzyme activity across broad ranges of K(+), Ca(2+), and Mg(2+) concentrations.
    Title: Thermodynamics of Cation Binding to the Sarcoendoplasmic Reticulum Calcium ATPase Pump and Impacts on Enzyme Function.
  3. Phospholamban (PLB) oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase (SERCA) binding were quantified by fluorescence resonance energy transfer (FRET) in an intact cellular environment.
    Title: Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells.
  4. interactions between the cytoplasmic domain of phospholamban and negatively charged phospholipids might play a role in moderating the regulation of SERCA, with implications for cardiac muscle contractility.
    Title: Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?
  5. functional studies and three new crystal structures of the rabbit skeletal muscle Ca2+-ATPase.
    Title: The structural basis of calcium transport by the calcium pump.
  6. Protonation of the Ca(2+) ligands of the SR Ca(2+)-ATPase (SERCA1a) was studied by a combination of rapid scan FTIR spectroscopy and electrostatic calculations.
    Title: Protonation and hydrogen bonding of Ca2+ site residues in the E2P phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase studied by a combination of infrared spectroscopy and electrostatic calculations.
  7. the major SR membrane lipid PC is optimal for all steps and, unlike the other headgroups, contributes favorable electrostatics and non-electrostatic elements during the Ca-ATPase transition
    Title: Nanodisc-based kinetic assays reveal distinct effects of phospholipid headgroups on the phosphoenzyme transition of sarcoplasmic reticulum Ca(2+)-ATPase.
  8. ATP-dependent Ca(2+) transport by SERCA in single giant unilamellar vesicles was detected directly using confocal fluorescence microscopy.
    Title: Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.
  9. Glycine 105 as Pivot for a Critical Knee-like Joint between Cytoplasmic and Transmembrane Segments of the Second Transmembrane Helix in Ca2+-ATPase.(
    Title: Glycine 105 as Pivot for a Critical Knee-like Joint between Cytoplasmic and Transmembrane Segments of the Second Transmembrane Helix in Ca2+-ATPase.
  10. Here we describe the methods to analyze these processes in the transport cycle with a representative member of P-type ATPase family, SERCA1a, sarco(endo)plasmic reticulum Ca(2+)-ATPase
    Title: Phosphorylation/Dephosphorylation Assays.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Names
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATPase, Ca++ transporting, ubiquitous
SERCA1
SR Ca(2+)-ATPase 1
calcium pump 1
endoplasmic reticulum class 1/2 Ca(2+) ATPase
NP_001082787.1
XP_069919843.1
XP_069919844.1
XP_069919845.1
XP_069919846.1
XP_069919847.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089318.1 → NP_001082787.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 1

    See identical proteins and their annotated locations for NP_001082787.1

    Status: PROVISIONAL

    Source sequence(s)
    M12898
    UniProtKB/Swiss-Prot
    P04191, P11719
    UniProtKB/TrEMBL
    G1SI34
    Related
    ENSOCUP00000002327.4, ENSOCUT00000002689.4
    Conserved Domains (1) summary
    cd02083
    Location:5 → 989
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091450.1 Reference mOryCun1.1

    Range
    7716129..7732446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_070063744.1 → XP_069919845.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X3

    UniProtKB/TrEMBL
    G1SI34

  2. XM_070063742.1 → XP_069919843.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1

    UniProtKB/TrEMBL
    G1SI34

  3. XM_070063746.1 → XP_069919847.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X5

    UniProtKB/TrEMBL
    G1SI34

  4. XM_070063743.1 → XP_069919844.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2

    UniProtKB/TrEMBL
    G1SI34

  5. XM_070063745.1 → XP_069919846.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X4

    UniProtKB/TrEMBL
    B6CAM1, G1SI34
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04191.1 GenPept UniProtKB/Swiss-Prot:P04191

Gene LinkOut

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