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NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 [ Homo sapiens (human) ]

Gene ID: 10003, updated on 23-Nov-2021

Summary

Official Symbol
NAALAD2provided by HGNC
Official Full Name
N-acetylated alpha-linked acidic dipeptidase 2provided by HGNC
Primary source
HGNC:HGNC:14526
See related
Ensembl:ENSG00000077616 MIM:611636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP3; GCPIII; GPCIII
Summary
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Broad expression in testis (RPKM 7.2), adrenal (RPKM 5.0) and 17 other tissues See more
Orthologs
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Genomic context

See NAALAD2 in Genome Data Viewer
Location:
11q14.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (90131693..90193577)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89867831..89926062)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 49C Neighboring gene tripartite motif containing 64E, pseudogene Neighboring gene upstream binding transcription factor like 1 Neighboring gene cysteine and histidine rich domain containing 1 Neighboring gene DISC1 fusion partner 1 Neighboring gene tubulin alpha pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26353, MGC116996

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carboxypeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables dipeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables dipeptidyl-peptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type peptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
N-acetylated-alpha-linked acidic dipeptidase 2
Names
N-acetylated alpha-linked acidic dipeptidase II
NAALADASE2
NAALADase II
glutamate carboxypeptidase III
NP_001287859.1
NP_005458.1
XP_016872532.1
XP_016872533.1
XP_016872534.1
XP_016872535.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300930.2NP_001287859.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 2

    See identical proteins and their annotated locations for NP_001287859.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AJ012370, AP000648, BC088727, BU618706, CN355388
    Consensus CDS
    CCDS73364.1
    UniProtKB/Swiss-Prot
    Q9Y3Q0
    UniProtKB/TrEMBL
    J3KNJ3
    Related
    ENSP00000320083.4, ENST00000321955.8
    Conserved Domains (3) summary
    cd08022
    Location:305552
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:110296
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:589704
    TFR_dimer; Transferrin receptor-like dimerization domain
  2. NM_005467.4NP_005458.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 1

    See identical proteins and their annotated locations for NP_005458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AJ012370, AK075390, AP000648, CN355388
    Consensus CDS
    CCDS8288.1
    UniProtKB/Swiss-Prot
    Q9Y3Q0
    Related
    ENSP00000432481.1, ENST00000534061.6
    Conserved Domains (4) summary
    cd08022
    Location:338585
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:110336
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:622737
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:58104
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    90131693..90193577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017044.2XP_016872533.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

  2. XM_017017046.2XP_016872535.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

  3. XM_017017043.2XP_016872532.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

    Conserved Domains (4) summary
    cd08022
    Location:373620
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:145371
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:657772
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:93139
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  4. XM_017017045.1XP_016872534.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

    Conserved Domains (4) summary
    cd08022
    Location:284531
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:56282
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:568683
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:450
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RNA

  1. XR_001747708.2 RNA Sequence

  2. XR_001747707.2 RNA Sequence

  3. XR_001747709.2 RNA Sequence

  4. XR_001747710.2 RNA Sequence

  5. XR_001747711.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_019805497.1 Reference GRCh38.p13 PATCHES

    Range
    40786..99017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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