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LOC100009135 defensin NP-4 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009135, updated on 9-Nov-2023

Summary

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Gene symbol
LOC100009135
Gene description
defensin NP-4
See related
Ensembl:ENSOCUG00000014572
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
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Genomic context

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Location:
chromosome: Un
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259165.1 (97488..100007, complement)

NW_026259165.1Genomic Context describing neighboring genes Neighboring gene defensin NP-3a Neighboring gene corticostatin-6 Neighboring gene macrophage cationic peptide 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_026259165 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity? Michaelson D, et al. J Leukoc Biol, 1992 Jun. PMID 1613398
  2. Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. Selsted ME, et al. J Biol Chem, 1985 Apr 25. PMID 3988726

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in antibacterial humoral response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in disruption of plasma membrane integrity in another organism IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response in mucosa IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neutrophil antibiotic peptide NP-4
Names
microbicidal peptide NP-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082299.1 → NP_001075768.1  neutrophil antibiotic peptide NP-4 precursor

    See identical proteins and their annotated locations for NP_001075768.1

    Status: PROVISIONAL

    Source sequence(s)
    M64601
    UniProtKB/Swiss-Prot
    P07467
    Conserved Domains (2) summary
    pfam00323
    Location:65 → 93
    Defensin_1; Mammalian defensin
    pfam00879
    Location:1 → 50
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NW_026259165.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    97488..100007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07467.2 GenPept UniProtKB/Swiss-Prot:P07467

Gene LinkOut

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Molecular Biology Databases
Research Materials