sh3bp1 SH3-domain binding protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sh3bp1provided by ZNC
Official Full Name: SH3-domain binding protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-121128-2
See related: Ensembl:ENSDARG00000078119 AllianceGenome:ZFIN:ZDB-GENE-121128-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of GTPase activity; regulation of Rac protein signal transduction; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (19208154..19232844)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (19086491..19111050)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk28b01.y1 (e-PCR)
- UniSTS:200744

fb78b01.x1 (e-PCR)
- UniSTS:203436

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular anatomical structure	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SH3 domain-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

19208154..19232844

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001345321.6 → XP_001345357.4 SH3 domain-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M1PZW1, E7FFF8

Related

ENSDARP00000097940.2, ENSDART00000110415.4

Conserved Domains (2) summary

cd07620
Location:12 → 249

BAR_SH3BP1; The Bin/Amphiphysin/Rvs (BAR) domain of SH3-domain Binding Protein 1

cl02570
Location:244 → 446

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

Range

453509..469751

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474252.1 → XP_021329927.1 SH3 domain-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A8M9PFG1

Conserved Domains (3) summary

cl02570
Location:174 → 376

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:1 → 179

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl26464
Location:373 → 580

Atrophin-1; Atrophin-1 family