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cpa6 carboxypeptidase A6 [ Danio rerio (zebrafish) ]

Gene ID: 100002342, updated on 17-Sep-2024

Summary

Official Symbol
cpa6provided by ZNC
Official Full Name
carboxypeptidase A6provided by ZNC
Primary source
ZFIN:ZDB-GENE-091204-331
See related
Ensembl:ENSDARG00000012013 AllianceGenome:ZFIN:ZDB-GENE-091204-331
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-78n18.1
Summary
Enables carboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including head; pectoral fin; pectoral fin bud; segmental plate; and tail bud. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See cpa6 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (18883401..18919571, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (18738101..18760145, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) Neighboring gene si:dkey-4m13.3 Neighboring gene phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Neighboring gene zgc:162928

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    18883401..18919571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470305.2XP_021325980.1  carboxypeptidase A6

    UniProtKB/TrEMBL
    A0A8M9PXW2, E7F2H8
    Related
    ENSDARP00000096966.4, ENSDART00000106188.6
    Conserved Domains (2) summary
    pfam02244
    Location:46122
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:141440
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins