Similar studies for GEO DataSets (Select 3904) - GEO DataSets

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Items: 20

Select item 39041.

Directed differentiation of embryonic stem cells and induced pluripotent stem cells

Analysis of ES cells and iPS cells before (day 0) and after (day 5) endodermal differentiation. E8.25 embryonic definitive endoderm (DE) was also examined. Results provide insight into the relative equivalency of DE derived from ES/iPS cells in vitro and authentic DE from embryos in vivo.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 cell type, 3 development stage, 2 strain sets

Platform:: GPL6246
Series:: GSE27087
30 Samples

Download data: CEL

DataSet

Accession:: GDS3904

ID:: 3904

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000270872.

Mouse embryonic and induced pluripotent stem cells can form definitive endoderm despite differences in imprinted genes

(Submitter supplied) The directed differentiation of induced pluripotent stem (iPS) and embryonic stem (ES) cells into definitive endoderm (DE) would allow the derivation of otherwise inaccessible progenitors for endodermal tissues. However, a global comparison of the relative equivalency of DE derived from iPS and ES populations has not been performed. Recent reports of molecular differences between iPS and ES cells have raised uncertainty as to whether iPS cells could generate autologous endodermal lineages in vitro. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3904
Platform:: GPL6246
30 Samples

Download data: CEL

Series

Accession:: GSE27087

ID:: 200027087

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000134723.

Functional Heterogeneity of Embryonic Stem Cells Revealed Through Translational Amplification of an Early Endodermal Transcript

(Submitter supplied) Identification of transcripts in different subpopulations of the HIV mouse ES cell line growing under self-renewing conditions (+Lif, +10FCS, GMEM media and plated on gelatin coated dishes). Subpopulations were identified and isolated based on the expression of the cell surface marker, SSEA 1 (a marker of murine ES cells) and expression of the venus protein, the cDNA of which was knocked into the Hex locus (Hhex). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6867
8 Samples

Download data: TXT

Series

Accession:: GSE13472

ID:: 200013472

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000108094.

Global gene expression from SOX7 and SOX17 over-expressing human embryonic stem cells (CA1 and CA2 lines)

(Submitter supplied) This study aimed to understand the transcriptional networks regulating endoderm specification from HESC and therefore explored the phenotype of CA1 and CA2 HESC constitutively over-expressing SOX7 or SOX17. Cell lines were created using an inducible construct whereby clonal populations containing transgene integration are selected by Neomycin resistance without expressing of the gene of interest (NoCre controls). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3300
Platform:: GPL570
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE10809

ID:: 200010809

Select item 33005.

SOX transcription factor overexpression in embryonic stem cells

Analysis of CA1 and CA2 embryonic stem cell (ESC) lines over-expressing transcription factor SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm progenitors, respectively. Results provide insight into the roles of SOX7 and SOX17 as regulators of endoderm differentiation in ESCs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 cell line, 3 protocol sets

Platform:: GPL570
Series:: GSE10809
8 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3300

ID:: 3300

Select item 2000413616.

Role for DNA methylation in Gata4-binding in embryonic stem cells-derived mesoderm

(Submitter supplied) During embryogenesis, many key transcription factors are used repeatedly, achieving different outcomes depending on cell type and developmental stage. The epigenetic modification of the genome functions as a memory of a cell’s developmental history, and it has been proposed that such modification shapes the cellular response to transcription factors. To investigate the role of DNA methylation in the response to transcription factor Gata4, we have tried to identify GATA4-binding associated genes of WT-type and Dnmt3a-/-Dnmt3b-/-(DKO) in Flk1-based mesoderm progenitor by Gata4 ChIP-analysis.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE41361

ID:: 200041361

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000368147.

Role for DNA methylation in response to Gata4 activation in embryonic stem cell-derived mesoderm

(Submitter supplied) During embryogenesis, many key transcription factors are used repeatedly, achieving different outcomes depending on cell type and developmental stage. The epigenetic modification of the genome functions as a memory of a cell’s developmental history, and it has been proposed that such modification shapes the cellular response to transcription factors. To investigate the role of DNA methylation in the response to transcription factor Gata4, we examined expression profiles of Dnmt3a-/-Dnmt3b-/- ES cell-derived mesoderm cells cultured for 4 days with or without Gata4 activation, as well as the wild-type counterparts, using Affymetrix microarrays.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
20 Samples

Download data: CEL, EXP

Series

Accession:: GSE36814

ID:: 200036814

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000363138.

DNA Methylation Restricts Lineage-Specific Functions of Transcription Factor Gata4 during Embryonic Stem Cell Differentiation

(Submitter supplied) DNA methylation changes dynamically during development and is essential for embryogenesis in mammals. However, how DNA methylation affects developmental gene expression and cell differentiation remains elusive. During embryogenesis, many key transcription factors are used repeatedly, triggering different outcomes depending on the cell type and developmental stage. Here, we report that DNA methylation modulates transcription-factor output in the context of cell differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
108 Samples

Download data: TXT

Series

Accession:: GSE36313

ID:: 200036313

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000157759.

Generation of induced pluripotent stem cells by efficient reprogramming of adult bone marrow cells

(Submitter supplied) Reprogramming of somatic cells provides potential for the generation of specific cell types, which could be a key step in the study and treatment of human diseases. In vitro reprogramming of somatic cells into a pluripotent embryonic stem (ES) cell–like state has been reported by retroviral transduction of murine fibroblasts using four embryonic transcription factors or through cell fusion of somatic and pluripotent stem cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
4 Samples

Download data: TXT

Series

Accession:: GSE15775

ID:: 200015775

Select item 20002686210.

Expression data of human eGFP-SOX17+ endoderm cells

(Submitter supplied) Using homologous recombination in human ESC, we inserted an enhanced green fluorescent protein (eGFP) transgene into a locus encoding a postulated marker of human endoderm, SOX17 in H9 human embryonic stem cells. This allowed purification of SOX17+ hESC endodermal progeny by fluorescence activated cell sorting (FACS) to generate microarray gene expression profile.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE26862

ID:: 200026862

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003763111.

Human Pluripotent Cell Derived Endothelial Cell Characterization

(Submitter supplied) Human ES or iPS Cells were differentiated into endothelial cells (ECs) defined by expression of CD31 (PECAM1) and CD144 (VE-Cadherin) on the cell surface. All ES or iPS derived ECs were greater than 90% double positive for these two markers. These in vitro derived ECs were compared to each other and to ECs from primary cell sources; arterial (aortic Ecs), venous (saphenous vein) and lymphatic.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
12 Samples

Download data: CEL

Series

Accession:: GSE37631

ID:: 200037631

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001956412.

Comparative Analysis of Extraembryonic Endoderm Cells with Cardiac Inducing Ability

(Submitter supplied) Comparative analysis of Endodermal-like cell lines with demonstrated ability to support myocardial differentiation

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
9 Samples

Download data: TXT

Series

Accession:: GSE19564

ID:: 200019564

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005627613.

Imprinted expression is different in visceral yolk sac and cystic embryoid body endoderm

(Submitter supplied) Genomic imprinting is an epigenetic phenomenon resulting in parent-of-origin mono-allelic expression of a small subset of mammalian genes. Imprinted genes have been categorized into two groups: multi lineage (ML) imprinted genes that can show imprinted expression in both embryonic and extra-embryonic lineages, and genes that show extra-embryonic lineage (EXEL) specific imprinted expression restricted to tissues like the placenta and visceral yolk sac (VYS) endoderm. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
19 Samples

Download data: BED, BW, TXT

Series

Accession:: GSE56276

ID:: 200056276

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001669014.

A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL8733 GPL7363
29 Samples

Download data: CEL

Series

Accession:: GSE16690

ID:: 200016690

Select item 20001668915.

MicroRNA expression data from differentiation of human H9 ESCs into definitive endoderm on MEF feeder layers

(Submitter supplied) Pluripotent hESCs can differentiate into the three primary embryonic lineages (endoderm, mesoderm, ectoderm) as well as extraembryonic tissues. Definitive endoderm (DE) is the first step into the pathway to endoderm dreived tissues (pancreas, liver, gut, lung). We used microarrays to detail the changes in microRNA expression during the transition from pluripotent hESCs into definitive endoderm.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8733
6 Samples

Download data: CEL

Series

Accession:: GSE16689

ID:: 200016689

Select item 20001668716.

MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm on MEF feeder layers

(Submitter supplied) Pluripotent hESCs can differentiate into the three primary embryonic lineages (endoderm, mesoderm, ectoderm) as well as extraembryonic tissues. Definitive endoderm is the first step into the pathway to endoderm dreived tissues (pancreas, liver, gut, lung) We used microarrays to detail the changes in microRNA expression during the transition from pluripotent hESCs into definitive endoderm

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8733
6 Samples

Download data: CEL

Series

Accession:: GSE16687

ID:: 200016687

Select item 20001668117.

mRNA expression data from differentiation of human ESCs into definitive endoderm, Cyt49 on matrigel

(Submitter supplied) hESCs can differentiate into the three primary embryonic lineages (endoderm, mesoderm, ectoderm) as well as extraembryonic tissues. Definitive endoderm (DE) is the first step into the pathway to endoderm derived tissues: pancreas, liver, gut, lung. We used microarrays to detail the changes in mRNA expression during the transition from pluripotent hESCs into definitive endoderm.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL7363
9 Samples

Download data: TXT

Series

Accession:: GSE16681

ID:: 200016681

Select item 20001667818.

MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm in feeder-free conditions

(Submitter supplied) Pluripotent hESCs can differentiate into the three primary embryonic lineages (endoderm, mesoderm, ectoderm) as well as extraembryonic tissues. Definitive endoderm is the first step into the pathway to endoderm dreived tissues (pancreas, liver, gut, lung). We used microarrays to detail the changes in microRNA expression during the transition from pluripotent hESCs into definitive endoderm.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8733
8 Samples

Download data: CEL

Series

Accession:: GSE16678

ID:: 200016678

Select item 20001757919.

Comparative global transcriptomic profiling of human ES and iPSs cells and their derived microdissected cardiac clusters

(Submitter supplied) Recent establishment of induced pluripotent stem (iPS) cells opened new avenues for generating human patient-specific stem cell derivatives that can be used for in vitro modeling of human disease, drug development and cell replacement therapy. In this study we analyzed the molecular and functional properties of cardiomyocytes (CM) differentiated from human iPS cells. Clusters of synchronously beating cells were first observed at day 11 of iPS cell differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
18 Samples

Download data: TXT

Series

Accession:: GSE17579

ID:: 200017579

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001275320.

Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells

(Submitter supplied) We showed the function of Rex1 in mouse ES cells as well as in embryos using the conventional gene targeting strategy. Our results clearly indicated that Rex1 function is dispensable for both the maintenance of pluripotency in ES cells and the development of embryos. However, Rex1-/- ES cells showed the defect to induce a subset of the marker genes of visceral endoderm, when differentiated as embryoid body, as found in EC cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL922
12 Samples

Download data: TXT

Series

Accession:: GSE12753

ID:: 200012753

PubMed Full text in PMC Similar studies Analyze with GEO2R

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