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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

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LiverTox – Editors and External Expert Review Panel

Last Update: September 3, 2019.

Senior Editor

Jay H. Hoofnagle, M.D. is the senior editor and primary author of LiverTox, responsible for researching the scientific literature, writing drug monographs and for writing clinical overviews related to drug induced liver injury. Dr. Hoofnagle is a graduate of Yale Medical School and did post-graduate training in internal medicine, gastroenterology and hepatology. He has been a senior investigator in liver disease in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) for more than 30 years and is currently Director of the Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, NIDDK. In that capacity, he administers a basic and clinical research portfolio that examines the pathogenesis of liver diseases and oversees clinical research networks such as the Drug-Induced Liver Injury Network. Dr. Hoofnagle is a former president of the American Association for Liver Disease. He is the author of more than 400 articles in the medical literature and has conducted both clinical and basic research on liver diseases including hepatitis A, B, C, D and E as well as nonalcoholic steatohepatitis, autoimmune liver diseases and drug induced liver disease.

Deputy Editor

James E. Knoben, Pharm.D. is the deputy editor of LiverTox and he provides expertise in drug classification and ensures integrity of the data within LiverTox. Dr. Knoben is a graduate of the University of California and holds an M.P.H. degree from Yale University Medical School. He has extensive experience in biomedical writing, including serving 30 years as co-editor of a drug information handbook that was utilized worldwide in clinical education and practice. He served 12 years as director of the Division of Drug Information Resources in the Food and Drug Administration, and more recently as drug information consultant to the National Library of Medicine, NIH.

Administrative Assistant

Ms. Marge Worrest is the administrative assistant in support of LiverTox. Ms. Worrest is a graduate of Keystone College and has served in program management positions for several government agencies, including the Department of Defense in Strategic Planning, Budget and Program Finance, and the Department of Homeland Security in Program Budget and Mission Support-Reimbursable Programs and is a Certified Greenbelt in Six Sigma Lean practices. Ms. Worrest is responsible for developing schedules of updating, editing and outside review of the LiverTox website. She is responsible for the management of the External Expert Review Panel and the flow of the Panel’s reviews and updates of LiverTox.

External Expert Review Panel

The LiverTox External Expert Review Panel is comprised of three non-federal subject experts in drug induced liver injury, hepatology, pharmacology and/or herbal supplement safety. The members are appointed by the NIDDK and serve 3-year, renewable terms. The review panel provides oversight of the LiverTox database with respect to assessing new content and revisions/updates of current content; advising on improvements to the accuracy, format, reliability and usefulness of the site; and advising on policies governing the LiverTox website. The Expert Review Panel is also responsible for ensuring accurate peer review of all new material added to LiverTox. Currently, the review panel consists of the following individuals:

Adrian M. Di Bisceglie, M.D. received his medical degree from the University of Witwatersrand, Johannesburg, South Africa and completed his training in Internal Medicine at Baragwanath Hospital, Johannesburg before doing a research fellowship at the National Institutes of Health (NIH) where he went on to become chief of the Liver Diseases Section, NIDDK. He is currently a Professor of Internal Medicine at Saint Louis University where he served as department chairman from 2006 to 2017. Dr. Di Bisceglie served on the governing board of the American Association for the Study of Liver Disease (AASLD) and was President of that organization in 2014. He has served on the editorial boards of many journals including Hepatology, Liver Transplantation and as Section Editor on Hepatitis C for UpToDate. Dr. Di Bisceglie has received numerous awards including the AASLD Distinguished Service Award and Outstanding St. Louis Scientist Award from the Academy of Science of St. Louis.

Herbert L. Bonkovsky, M.D. is board certified in internal medicine and gastroenterology. Dr. Bonkovsky is Professor of Medicine and Molecular Medicine & Translational Research, and Director of the Liver and Metabolic Disorders Laboratory at Wake Forest University/NC Baptist Medical Center.

Raj Vuppalanchi, M.D. is board certified in Gastroenterology and currently serves as the Director of Clinical Hepatology at Indiana University School of Medicine, Indianapolis. He is a Professor of Medicine and provides care to patients with various liver disorders. He has served as a co-investigator with Drug-Induced Liver Injury Network and published on the topics of drug-induced liver injury (DILI) and drug metabolism. He is a clinical investigator with wide experience in using novel therapeutics for the treatment of various liver disorders and also provides expertise in hepatic safety assessment through participation in data safety monitoring boards (DSMB).

Ad Hoc Members of the External Expert Review Panel

The expert review panel may include ad hoc members, including other experts in drug induced liver injury from NIDDK and other NIH Institutes such as the National Library of Medicine and Office of Dietary Supplements as well as from the Food and Drug Administration and other Federal Agencies. The composition of the panel is subject to change as the database evolves.

Jose Serrano, M.D., Ph. D. is a physician scientist with postgraduate training in internal medicine, gastroenterology and hepatology. As a Senior Scientific Officer in the Division of Digestive Diseases and Nutrition (NIDDK), he administers a basic and clinical research portfolio in a broad area of gastrointestinal diseases and since 2004 has been the Project Scientist for the Drug Induced Liver Injury Network (DILIN).


Editorial and informatics support is provided by the National Center for Biotechnology Information, National Library of Medicine, NIH, which hosts the LiverTox website in Bookshelf, a site that provides access to books and documents in healthcare and life science.


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